Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1

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dc.authoridTR231039en_US
dc.authoridTR102040en_US
dc.authoridTR52354en_US
dc.authoridTR242544en_US
dc.authoridTR103979en_US
dc.contributor.authorKaya, Kürşat
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorÇetin, Aslı
dc.contributor.authorTecellioğlu, Mehmet
dc.contributor.authorBaşak, Neşe
dc.date.accessioned2017-04-17T12:07:10Z
dc.date.available2017-04-17T12:07:10Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and βg were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.en_US
dc.identifier.citationKaya, K. Çiftçi, O. Çetin, A. Tecellioğlu, M. Başak, N. (2016). Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1. Acta Cir Brasl. 31 (3). 198-205.en_US
dc.identifier.endpage205en_US
dc.identifier.issue3en_US
dc.identifier.startpage198en_US
dc.identifier.urihttp://dx.doi.org/10.1590/S0102-865020160030000008
dc.identifier.urihttps://hdl.handle.net/11616/6676
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherActa cir braslen_US
dc.relation.ispartofActa cir braslen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectBeta-Glucansen_US
dc.subjectNervous Systemen_US
dc.subjectOxidative Stressen_US
dc.subjectRasten_US
dc.titleBeneficial effects of glucan against cisplatin side effects on the nervous system in rats 1en_US
dc.typeArticleen_US

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