Glucagon-like peptide-1 receptor agonists associated with improved clinical outcomes in patients with inflammatory bowel disease: a retrospective cohort study

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dc.contributor.authorAksan, Feyzullah
dc.contributor.authorAbboud, Alan
dc.contributor.authorTanriverdi, Lokman H.
dc.contributor.authorAroniadis, Olga C.
dc.contributor.authorMonzur, Farah
dc.date.accessioned2026-04-04T13:37:35Z
dc.date.available2026-04-04T13:37:35Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated anti-inflammatory effects in preclinical models of inflammatory bowel disease (IBD), yet clinical data remain limited. This study aimed to assess the association between GLP-1 RAs exposure and disease-related outcomes, treatment patterns, and healthcare utilization in patients with IBD. We conducted a retrospective, propensity score-matched cohort study using data from the TriNetX Analytics Research Network. Adults diagnosed with Crohn's disease or ulcerative colitis between 2006 and 2022 were matched 1:1 based on GLP-1 RAs exposure. Patients with confounding comorbidities were excluded. Key outcomes included 5-year mortality, IBD-related surgeries and complications, medication use, and healthcare utilization. A total of 11,016 matched IBD patients were included (GLP-1 RAs: n = 5508; no GLP-1 RAs: n = 5508). Exposure to GLP-1 RAs was associated with a significantly lower 5-year mortality rate (8.05% vs 10.03%, hazard ratio [HR] 0.65, 95% confidence interval [CI] 0.54-0.78, p < 0.0001). Rates of IBD-related surgeries (HR 0.53, 95% CI 0.39-0.72) and complications (HR 0.81, 95% CI 0.70-0.93) were also reduced. Moreover, patients in the GLP-1 RAs group experienced fewer overall healthcare encounters (chi(2) = 136.52, p < 0.0001). Significant differences were observed in corticosteroid (p < 0.0001) and advanced biologic use (p < 0.0001), although rank biserial correlation was small (0.04 and - 0.11, respectively), and findings on medication use did not persist in subgroup analyses of ulcerative colitis and Crohn's disease patients. Our findings suggest a potential disease-modifying effect of GLP-1 RAs beyond glycemic control, especially in reducing mortality, complications, surgeries, and healthcare use. However, the clinical relevance of reduced medication use warrants further investigation through prospective trials.
dc.identifier.doi10.1007/s00210-025-04745-0
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.orcid0000-0003-4263-5234
dc.identifier.orcid0000-0002-6994-0565
dc.identifier.orcid0000-0001-7974-0025
dc.identifier.orcid0000-0001-6501-0769
dc.identifier.pmid41143957
dc.identifier.scopus2-s2.0-105019781215
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00210-025-04745-0
dc.identifier.urihttps://hdl.handle.net/11616/109914
dc.identifier.wosWOS:001603068900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectGlucagon-like peptide-1 receptor agonists
dc.subjectInflammatory bowel disease
dc.subjectUlcerative colitis
dc.subjectCrohn's disease
dc.subjectIBD-related complications
dc.subjectHealth care utilization
dc.titleGlucagon-like peptide-1 receptor agonists associated with improved clinical outcomes in patients with inflammatory bowel disease: a retrospective cohort study
dc.typeArticle

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