The investigation of levels of the peptide adrenomedullin (ADM) and the enzyme tyrosine hydroxylase (TH) in rat tissue after exposure to physiological stress
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An organism's ability to respond to the external and internal environments is explained in terms of the concept of biological stress. The causes of these responses are called stressors. They may be physical, chemical, emotional, or traumatic. With continued exposure to the stressor the organism enters the stage of resistance and defense. After prolonged exposure to the same stressor the organism may enter the stage of exhaustion. Catecholamines have an important role in maintaining biological homeostasis to stress. Catecholamine biosynthesis starts from tyrosine and in the first step DOPA is synthesized from tyrosine and catalyzed by the enzyme tyrosine hydroxylase (TH). In rats this enzyme activity varies depending on cold stress, exercise and age. The production of adrenomedullin in adrenal medulla, heart and brain also suggest a role for this peptide in the physiological control of homeostasis. In this study TH enzyme activity and adrenomedullin levels were investigated in rat tissues that were excised from animals exposed to 8 degrees C cold for 3 weeks. After cold exposure TH enzyme activities and adrenomedullin levels were changed but also age was found to be a factor. Copyright (c) 2006 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
adrenomedullin, tyrosine hydroxylase, cold stress, aging
Kaynak
Stress and Health
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
22
Sayı
2
