The investigation of levels of the peptide adrenomedullin (ADM) and the enzyme tyrosine hydroxylase (TH) in rat tissue after exposure to physiological stress

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorYurekli, M
dc.contributor.authorYarpuzlu, AA
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAn organism's ability to respond to the external and internal environments is explained in terms of the concept of biological stress. The causes of these responses are called stressors. They may be physical, chemical, emotional, or traumatic. With continued exposure to the stressor the organism enters the stage of resistance and defense. After prolonged exposure to the same stressor the organism may enter the stage of exhaustion. Catecholamines have an important role in maintaining biological homeostasis to stress. Catecholamine biosynthesis starts from tyrosine and in the first step DOPA is synthesized from tyrosine and catalyzed by the enzyme tyrosine hydroxylase (TH). In rats this enzyme activity varies depending on cold stress, exercise and age. The production of adrenomedullin in adrenal medulla, heart and brain also suggest a role for this peptide in the physiological control of homeostasis. In this study TH enzyme activity and adrenomedullin levels were investigated in rat tissues that were excised from animals exposed to 8 degrees C cold for 3 weeks. After cold exposure TH enzyme activities and adrenomedullin levels were changed but also age was found to be a factor. Copyright (c) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/smi.1080
dc.identifier.endpage80en_US
dc.identifier.issn1532-3005
dc.identifier.issn1532-2998
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33646425884en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.1002/smi.1080
dc.identifier.urihttps://hdl.handle.net/11616/94375
dc.identifier.volume22en_US
dc.identifier.wosWOS:000237367400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofStress and Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjecttyrosine hydroxylaseen_US
dc.subjectcold stressen_US
dc.subjectagingen_US
dc.titleThe investigation of levels of the peptide adrenomedullin (ADM) and the enzyme tyrosine hydroxylase (TH) in rat tissue after exposure to physiological stressen_US
dc.typeArticleen_US

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