Is There a Predictive Factor for an Association with Autoimmune Glandular Disease in Children Diagnosed with Celiac Disease?

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dc.authoridÇamtosun, Emine/0000-0002-8144-4409
dc.authoridVarol, İlknur fatma/0000-0001-5212-218X;
dc.authorwosidÇamtosun, Emine/AAE-3945-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.authorwosidgungor, sukru/JNR-9592-2023
dc.contributor.authorVarol, Fatma Ilknur
dc.contributor.authorCamtosun, Emine
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.contributor.authorGungor, Sukru
dc.date.accessioned2024-08-04T20:10:15Z
dc.date.available2024-08-04T20:10:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: A close relationship has been suggested between Celiac disease (CD) and glandular autoimmunity. The aim of this study was to determine the predictive factors for autoimmune glandular disease (AGD) in children with CD.Methods: The study included 228 pediatric patients, diagnosed with CD between 2010 and 2019. The cases with AGD (Group 1) and those without AGD (Group 2) and the patients with type 1 diabetes mellitus (T1DM) (Group A) and those without T1DM (Group B) were retrospectively reviewed and compared in terms of clinical and laboratory features.Results: AGD was detected in 8.8% (n=20) of the patients: T1DM in 13 (65%), T1DM and Hashimoto's thyroiditis (HT) in 3 (15%), HT only in 2 (10%), T1DM and Graves disease (GD) in 1 (5%), and GD only in 1(5%). The mean age at the diagnosis of CD was significantly higher in Group 1 (10.93 +/- 4.15 years) compared to Group 2 (8.10 +/- 4.19 years) (p<0.05) and also was significantly higher in Group A compared to Group B (p<0.05). Most of the diagnoses of AGD were made before the diagnosis of CD and age was an effective factor. There was no difference between Group 1 and Group 2 and Group A and Group B in terms of gender, typical/atypical CD ratio, tissue transglutaminase IgA (TTGA) level, human leucocyte antigen (HLA)-DQ2 and/or HLA-DQ8 positivity rate, and histopathological stage.Conclusion: Although patients with a diagnosis of co-existent CD and AGD were significantly older than patients with isolated CD, gender, celiac symptoms, TTGA level, HLA type, and histopathological stage had no predictive value for the coexistence of AGD in patients with CD.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2022.2022-2-14
dc.identifier.endpage414en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue4en_US
dc.identifier.pmid35770950en_US
dc.identifier.scopus2-s2.0-85143180738en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage409en_US
dc.identifier.trdizinid1173365en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2022.2022-2-14
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1173365
dc.identifier.urihttps://hdl.handle.net/11616/92684
dc.identifier.volume14en_US
dc.identifier.wosWOS:000908310600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoimmune glandular diseaseen_US
dc.subjectCeliac diseaseen_US
dc.subjectchilden_US
dc.subjectdiabetes mellitus type 1en_US
dc.subjectGraves diseaseen_US
dc.subjectHashimoto?s thyroiditisen_US
dc.titleIs There a Predictive Factor for an Association with Autoimmune Glandular Disease in Children Diagnosed with Celiac Disease?en_US
dc.typeArticleen_US

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