Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning

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dc.contributor.authorCanbaz, Hayri
dc.contributor.authorBestemir, Attila
dc.contributor.authorAkbulut, Sami
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorYavuz, Yusuf
dc.date.accessioned2026-04-04T13:30:45Z
dc.date.available2026-04-04T13:30:45Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning. Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed. Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. The patients were divided into two groups: alive (n = 18) and dead (n = 8). No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). On the other hand, there were statistically significant differences between the alive and dead groups in terms of MELD score (P = .016; 23 vs. 34), re-transplantation (P = .022; 0% vs. 37.5%), hospital stay (P = .004; 24 vs. 6 days), and follow up (P < .001; 3423 vs. 5 days). Conclusions: This study showed that mortality was higher in patients with high MELD scores and patients who underwent re-transplantation. However, this study needs to be supported by multicenter prospective studies.
dc.identifier.doi10.5152/tjg.2024.24226
dc.identifier.issn2148-5607
dc.identifier.issue2
dc.identifier.orcid0000-0003-0986-9039
dc.identifier.orcid0000-0002-8044-0297
dc.identifier.orcid0000-0002-6864-7711
dc.identifier.orcid0000-0001-6989-7854
dc.identifier.pmid39632787
dc.identifier.scopus2-s2.0-85217750184
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1346641
dc.identifier.urihttps://doi.org/10.5152/tjg.2024.24226
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1346641
dc.identifier.urihttps://hdl.handle.net/11616/108355
dc.identifier.volume36
dc.identifier.wosWOS:001433257400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectLiver transplantation
dc.subjectacute liver failure
dc.subjectmushroom poisoning
dc.subjectprognosis
dc.titleLiver Transplantation for Acute Liver Failure due to Mushroom Poisoning
dc.typeArticle

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