A Revised Treatment Approach for Hospitalized Patients with Eosinophilic and Neutrophilic Exacerbations of Chronic Obstructive Pulmonary Disease

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dc.authoridOcakli, Birsen/0000-0001-6145-8638
dc.authoridDuman, Dildar/0000-0001-8680-8550
dc.authoridKoçak, Nagihan Dumuş/0000-0003-4028-2797
dc.authoridAKA AKTÜRK, ÜLKÜ/0000-0002-7903-1779
dc.authoridYalçınsoy, Murat/0000-0003-3407-7359
dc.authoridGungor, Sinem/0000-0002-1163-125X
dc.authoridtuncay, Eylem Acarturk/0000-0002-5046-1943
dc.authorwosidOcakli, Birsen/KVB-4408-2024
dc.authorwosidDuman, Dildar/GQH-4100-2022
dc.authorwosidKoçak, Nagihan Dumuş/AFM-4219-2022
dc.authorwosidAKA AKTÜRK, ÜLKÜ/JAI-8635-2023
dc.authorwosidYalçınsoy, Murat/ABI-1421-2020
dc.authorwosidGungor, Sinem/GPX-1807-2022
dc.authorwosidtuncay, Eylem Acarturk/GPX-1832-2022
dc.contributor.authorAksoy, Emine
dc.contributor.authorGungor, Sinem
dc.contributor.authorAgca, Meltem Coban
dc.contributor.authorOzmen, Ipek
dc.contributor.authorDuman, Dildar
dc.contributor.authorKocak, Nagihan Durmus
dc.contributor.authorAkturk, Ulku Aka
dc.date.accessioned2024-08-04T20:09:57Z
dc.date.available2024-08-04T20:09:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVES: The choice of treatment according to the inflammation type in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been of recent interest. This study investigated the role of novel biomarkers, hospital outcomes, and readmission rates in the first month in patients with eosinophilic or neutrophilic AECOPD. MATERIALS AND METHODS: We conducted a retrospective observational cohort study in a Chest Teaching Hospital with hospitalized AECOPD patients. Subjects' characteristics, hemogram results, C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), platelet/mean platelet volume (PLT/MPV), length of hospital stay, mortality, and steroid use were recorded. Eosinophilic AECOPD defined as peripheral blood eosinophilia (PBE) was >2% and neutrophilic AECOPD as PBE Q%. Readmission within 28 days of discharge was recorded. RESULTS: Of 2727(31.5% females) patients, eosinophilic AECOPD was found in 510 (18.7%) patients. Leucocytes, CRF,' NLR, and PLR were significantly higher in neutrophilic AECOPD than in eosinophilic AECOPD (p<0.001). Steroid use and mortality rate were 45% and 0.6% in eosinophilic AECOPD and 71%, and 1.4% in neutrophilic AECOPD, respectively (p=0.001, p=0.19). Age >75 years, albumin <2.5 g/dL, CRP >50 mg/dL, and PLT/MPV <20x103 were found to be risks factors for hospital mortality (p<0.05 each). Readmission rates within 28 days of discharge were 5% (n=136), and this rate was higher in eosinophilic AECOPD patients not taking steroids (p<0.001). CONCLUSION: NLR, PLR, and CRP levels were higher in neutrophilic AECOPD compared with eosinophilic AECOPD. These markers decreased with treatment in neutrophilic AECOPD. A PLT/MPV ratio of <20x103 resulted in an increased mortality rate. Thus, appropriate steroid therapy may reduce readmission rates in the first 28 days after discharge in eosinophilic AECOPD.en_US
dc.identifier.doi10.5152/TurkThoracJ.2018.18004
dc.identifier.endpage200en_US
dc.identifier.issn1302-7808
dc.identifier.issn1308-5387
dc.identifier.issue4en_US
dc.identifier.pmid30322438en_US
dc.identifier.scopus2-s2.0-85056571801en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage193en_US
dc.identifier.trdizinid308644en_US
dc.identifier.urihttps://doi.org/10.5152/TurkThoracJ.2018.18004
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/308644
dc.identifier.urihttps://hdl.handle.net/11616/92517
dc.identifier.volume19en_US
dc.identifier.wosWOS:000447618800007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Publishing Houseen_US
dc.relation.ispartofTurkish Thoracic Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseasesen_US
dc.subjectexacerbationen_US
dc.subjectperipheral eosinophiliaen_US
dc.subjectneutrophil to lymphocyte ratioen_US
dc.subjectsteroid treatmenten_US
dc.titleA Revised Treatment Approach for Hospitalized Patients with Eosinophilic and Neutrophilic Exacerbations of Chronic Obstructive Pulmonary Diseaseen_US
dc.typeArticleen_US

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