IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON LİVER AND LUNG CANCER CELL LINES

Basit Öğe Kaydı
dc.authorscopusid57222505412
dc.authorscopusid57211524435
dc.authorscopusid57214746101
dc.authorscopusid57478631600
dc.authorscopusid57909255600
dc.authorscopusid55643109200
dc.authorscopusid26024440900
dc.contributor.authorYüce H.
dc.contributor.authorTürkmen N.B.
dc.contributor.authorŞenkal S.
dc.contributor.authorÖzek D.A.
dc.contributor.authorBulut E.
dc.contributor.authorDoğan A.
dc.contributor.authorÜnüvar S.
dc.date.accessioned2024-08-04T20:03:43Z
dc.date.available2024-08-04T20:03:43Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity. Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways. Material and Method: HEP3B and A549 cell lines were used to determine the efficacy of patulin in the treatment of liver and lung cancers. Cell lines were exposed to increasing concentrations of patulin (1, 2.5, 5, 10, 25, 50, and 100 µM), followed by determination of cell viability, cell migration, and apoptosis by MTS assay, wound healing assay, and RT-PCR assays. Result and Discussion: Patulin caused a dose-dependent significant decrease in cell viability and cell migration in both cancer cell lines. It also promoted the induction of apoptosis in both cell lines. Our results showed that patulin can significantly reduce tumor growth in human liver and lung cancer cells in vitro. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1078080
dc.identifier.endpage404en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85138955557en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage393en_US
dc.identifier.trdizinid1118872en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1078080
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1118872
dc.identifier.urihttps://hdl.handle.net/11616/92040
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectA549en_US
dc.subjectapoptosisen_US
dc.subjectcanceren_US
dc.subjectHEP3Ben_US
dc.subjectmycotoxinen_US
dc.subjectpatulinen_US
dc.titleIN VITRO ANTITUMOR ACTIVITY OF PATULIN ON LİVER AND LUNG CANCER CELL LINESen_US
dc.title.alternativePATULİNİN KARACİĞER VE AKCİĞER KANSERİ HÜCRE HATLARI ÜZERİNDEKİ İN VİTRO ANTİTÜMÖR AKTİVİTESİen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu