Multidrug resistance of isolated microorganisms in occluded bile duct stents

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dc.authoridDEMIRBAG, Ali E./0000-0003-3852-868X
dc.authoridParlak, Erkan/0000-0003-2227-9818
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidDEMIRBAG, Ali E./AAA-4186-2021
dc.contributor.authorDemirbag, Ali E.
dc.contributor.authorKarademir, Ash
dc.contributor.authorParlak, Erkan
dc.contributor.authorSen, Sueha
dc.contributor.authorKarahan, Mehmet
dc.contributor.authorKayaalp, Cuenet
dc.contributor.authorSahin, Burhan
dc.date.accessioned2024-08-04T20:09:46Z
dc.date.available2024-08-04T20:09:46Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: Biliary stents have been used for benign or malignant biliary strictures, preoperative biliary drainage, resolution of biliary or pancreatic leaks, and dissolution treatment of non-extractable bile duct stones since 1979, and should be replaced at 3-6 month intervals. The aim of this cross-sectional pioneer study was to identify the in microorganisms in occluded bile duct stents and to determine incidence and diagnosis of multidrug resistance of the isolated microorganisms in stents and in blood cultures. Methods: Fifty-one patients (14F, 37M, mean age: 58.2 +/- 11.6 yr) with cholangitis due to occluded stents were studied consecutively and prospectively after stent replacement was done. Independent variables were age, gender, underlying disease, duration of disease, size, length and period of stents, and blood biochemistry. Dependent variables were microorganisms isolated from the stent content and blood of the patients and the results of antibiogram tests. Results: Primary disease was malignant in 25 (49.0%), stent size was 7F in 30 (58.8%), and stent length was 11 cm in 11 (21.6%) and 15 cm in 12 (23.5% of the patients. The mean period after the 1(st) stent application was 207.0 +/- 111.3 days and the last stent duration was 111.0 +/- 64.0 days. Isolated microorganisms from stents and blood, respectively, were Escherichia coli (E. coli) (43.4%, 20.8%), Klebsiella spp.. (17.1%, 17.0%), Pseudomonas aeruginosa (P. aeruginosa) (13.2%, 18.9%) and Enterococcus spp. (10.5%, 17.0%). Isolated microorganisms showed multidrug resistance at high percentages (81.6% for stent, 81.1% for blood). ALT, AST, ALP, and direct bilirubin levels showed statistically significant differences between the benign and malignant groups. Conclusion: All bile duct stents are contaminated by microorganisms, of which a high majority has multidrug resistance, and they frequently cause biliary sepsis. Biliary sepsis call be prevented by changing the stents periodically and by using proper antibiotic prophylaxis.en_US
dc.identifier.endpage40en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.pmid17450493en_US
dc.identifier.scopus2-s2.0-43549105637en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage33en_US
dc.identifier.trdizinid75792en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/75792
dc.identifier.urihttps://hdl.handle.net/11616/92401
dc.identifier.volume18en_US
dc.identifier.wosWOS:000254135600007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Gastroenterologyen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoccluded biliary stentsen_US
dc.subjectmicroorganismsen_US
dc.subjectbiliary sepsisen_US
dc.subjectmultidrug resistanceen_US
dc.titleMultidrug resistance of isolated microorganisms in occluded bile duct stentsen_US
dc.typeArticleen_US

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