Investigation of serum IgG subclass distributions and anti-HBs response in healthy adults after hepatitis B vaccination
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to evaluate the distribution of serum total lgG (tlgG) subtypes before and after hepatitis B vaccinations in young adults and the relationship between anti-HBs titers and tlgG subtypes. Thirty-eight young adults (29 female, 9 male; age range: 18-20 years) who were the students of Malatya Health Care Profession High School were included in the study. Their anti-HBs and total anti-HBc markers' were negative. The study group were immunized with 20 ?g/mL recombinant HBV vaccine intramuscularly (Engerix B) at 0, 1st, and 6th months. The tlgG subtype distributions before vaccination and anti-HBs and tlgG subtype distributions after vaccination were investigated. Serum samples were collected one month after the third dose vaccination, and anti-HBs were found negative (<10 IU/ml) in 8 subjects (21%), low positive (10-100 IU/ml) in 14 subjects (37%), and high positive (>100 lU/ml) in 16 subjects (42%). There was no difference between the response groups in terms of tlgG subtype distributions obtained before vaccination. After vaccination, while there was no increase in the tlgG subtypes in the unresponsive group, increased lgG1 levels were determined in low and high response groups. The lgG1 increment ratio was more evident in high response cases. We concluded that lgG1 subtype titer was the most important indicator for the evaluation of the efficacy of active HBV immunization.
Açıklama
Anahtar Kelimeler
Anti-HBs response, Hepatitis B immunization, IgG subclass
Kaynak
Mikrobiyoloji Bulteni
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
39
Sayı
4
