Investigation of serum IgG subclass distributions and anti-HBs response in healthy adults after hepatitis B vaccination

dc.authorscopusid23495365400
dc.authorscopusid7004897000
dc.authorscopusid6603062857
dc.authorscopusid55840809900
dc.contributor.authorDinç But A.
dc.contributor.authorErsoy Y.
dc.contributor.authorÖzerol I.H.
dc.contributor.authorFirat M.
dc.date.accessioned2024-08-04T19:59:25Z
dc.date.available2024-08-04T19:59:25Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the distribution of serum total lgG (tlgG) subtypes before and after hepatitis B vaccinations in young adults and the relationship between anti-HBs titers and tlgG subtypes. Thirty-eight young adults (29 female, 9 male; age range: 18-20 years) who were the students of Malatya Health Care Profession High School were included in the study. Their anti-HBs and total anti-HBc markers' were negative. The study group were immunized with 20 ?g/mL recombinant HBV vaccine intramuscularly (Engerix B) at 0, 1st, and 6th months. The tlgG subtype distributions before vaccination and anti-HBs and tlgG subtype distributions after vaccination were investigated. Serum samples were collected one month after the third dose vaccination, and anti-HBs were found negative (<10 IU/ml) in 8 subjects (21%), low positive (10-100 IU/ml) in 14 subjects (37%), and high positive (>100 lU/ml) in 16 subjects (42%). There was no difference between the response groups in terms of tlgG subtype distributions obtained before vaccination. After vaccination, while there was no increase in the tlgG subtypes in the unresponsive group, increased lgG1 levels were determined in low and high response groups. The lgG1 increment ratio was more evident in high response cases. We concluded that lgG1 subtype titer was the most important indicator for the evaluation of the efficacy of active HBV immunization.en_US
dc.identifier.endpage490en_US
dc.identifier.issn0374-9096
dc.identifier.issue4en_US
dc.identifier.pmid16544550en_US
dc.identifier.scopus2-s2.0-39049189991en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage483en_US
dc.identifier.urihttps://hdl.handle.net/11616/90617
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-HBs responseen_US
dc.subjectHepatitis B immunizationen_US
dc.subjectIgG subclassen_US
dc.titleInvestigation of serum IgG subclass distributions and anti-HBs response in healthy adults after hepatitis B vaccinationen_US
dc.title.alternativeHepatit B aşilamasindan sonra sa?likli erişkinlerde serum IgG alt tipleri ve anti-HBs yanitinin araştirilmasien_US
dc.typeArticleen_US

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