Investigation of serum IgG subclass distributions and anti-HBs response in healthy adults after hepatitis B vaccination
dc.authorscopusid | 23495365400 | |
dc.authorscopusid | 7004897000 | |
dc.authorscopusid | 6603062857 | |
dc.authorscopusid | 55840809900 | |
dc.contributor.author | Dinç But A. | |
dc.contributor.author | Ersoy Y. | |
dc.contributor.author | Özerol I.H. | |
dc.contributor.author | Firat M. | |
dc.date.accessioned | 2024-08-04T19:59:25Z | |
dc.date.available | 2024-08-04T19:59:25Z | |
dc.date.issued | 2005 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | The aim of this study was to evaluate the distribution of serum total lgG (tlgG) subtypes before and after hepatitis B vaccinations in young adults and the relationship between anti-HBs titers and tlgG subtypes. Thirty-eight young adults (29 female, 9 male; age range: 18-20 years) who were the students of Malatya Health Care Profession High School were included in the study. Their anti-HBs and total anti-HBc markers' were negative. The study group were immunized with 20 ?g/mL recombinant HBV vaccine intramuscularly (Engerix B) at 0, 1st, and 6th months. The tlgG subtype distributions before vaccination and anti-HBs and tlgG subtype distributions after vaccination were investigated. Serum samples were collected one month after the third dose vaccination, and anti-HBs were found negative (<10 IU/ml) in 8 subjects (21%), low positive (10-100 IU/ml) in 14 subjects (37%), and high positive (>100 lU/ml) in 16 subjects (42%). There was no difference between the response groups in terms of tlgG subtype distributions obtained before vaccination. After vaccination, while there was no increase in the tlgG subtypes in the unresponsive group, increased lgG1 levels were determined in low and high response groups. The lgG1 increment ratio was more evident in high response cases. We concluded that lgG1 subtype titer was the most important indicator for the evaluation of the efficacy of active HBV immunization. | en_US |
dc.identifier.endpage | 490 | en_US |
dc.identifier.issn | 0374-9096 | |
dc.identifier.issue | 4 | en_US |
dc.identifier.pmid | 16544550 | en_US |
dc.identifier.scopus | 2-s2.0-39049189991 | en_US |
dc.identifier.scopusquality | Q4 | en_US |
dc.identifier.startpage | 483 | en_US |
dc.identifier.uri | https://hdl.handle.net/11616/90617 | |
dc.identifier.volume | 39 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | tr | en_US |
dc.relation.ispartof | Mikrobiyoloji Bulteni | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anti-HBs response | en_US |
dc.subject | Hepatitis B immunization | en_US |
dc.subject | IgG subclass | en_US |
dc.title | Investigation of serum IgG subclass distributions and anti-HBs response in healthy adults after hepatitis B vaccination | en_US |
dc.title.alternative | Hepatit B aşilamasindan sonra sa?likli erişkinlerde serum IgG alt tipleri ve anti-HBs yanitinin araştirilmasi | en_US |
dc.type | Article | en_US |