Does the mean platelet volume have any importance in patients with acute pulmonary embolism?
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Wien
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim To determine whether an association exists between a known marker of platelet activation, mean platelet volume (MPV), and the severity of acute pulmonary embolism (APE), and to test whether it can be used as prognostic indicator in patients with high-risk pulmonary embolism (PE). Materials and methods The study included 209 consecutive patients with APE (106 male, 103 female, mean age 62.4 +/- 15.4 years) and 162 controls (86 male, 76 female) matched for age (60.5 +/- 14.3 years) and concomitant diseases. Contrast-enhanced spiral computerized tomography or ventilation-perfusion scintigraphy, echocardiography, and lower extremity venous Doppler ultrasound were performed on the patients with APE. D-dimer level, troponin, arterial blood gases, platelet count, and MPV were measured in serum. Results The MPV did not differ between the patients with APE and the controls (8.0 +/- 1.1 fL, 7.9 +/- 0.59 fL, p = 0.22). There were no significant differences in the value of MPV among the groups of patients with massive, submassive, and nonmassive PE (MPV: 8.3 +/- 0.9 fL, 8.1 +/- 1.0 fL, 7.9 +/- 1.1 fL, p = 0.08, respectively). The MPV was higher in non-survivors than survivors (8.6 +/- 1.1 vs. 7.9 +/- 1.1 fL, p = 0.02). There was a statistically weak correlation between MPV and mean pulmonary arterial pressure (r = 0.25, p < 0.001) and also between MPV and right ventricle diameter (r = 0.11, p = 0.045). Conclusions Our results suggest that a simple baseline determination of MPV at a single time point is not a reliable indicator to determine the severity of PE or for the diagnosis of APE, but it is possible that the MPV increases in nonsurvivors.
Açıklama
Anahtar Kelimeler
Mean platelet volume, Platelet activation, Pulmonary embolism
Kaynak
Wiener Klinische Wochenschrift
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
125
Sayı
13-14
