Does the mean platelet volume have any importance in patients with acute pulmonary embolism?

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dc.authoridTürkkan, Sinan/0000-0003-4029-419X
dc.authoridAytemur, Zeynep Ayfer/0000-0003-0421-907X
dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridErmis, Hilal/0000-0002-1764-9098
dc.authorwosidTürkkan, Sinan/HZL-1318-2023
dc.authorwosidTürkkan, Sinan/GZL-2401-2022
dc.authorwosidAytemur, Zeynep Ayfer/ABI-7452-2020
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.contributor.authorHilal, Ermis
dc.contributor.authorNeslihan, Yucel
dc.contributor.authorGazi, Gulbas
dc.contributor.authorSinan, Turkkan
dc.contributor.authorAyfer, Aytemur Zeynep
dc.date.accessioned2024-08-04T20:37:44Z
dc.date.available2024-08-04T20:37:44Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim To determine whether an association exists between a known marker of platelet activation, mean platelet volume (MPV), and the severity of acute pulmonary embolism (APE), and to test whether it can be used as prognostic indicator in patients with high-risk pulmonary embolism (PE). Materials and methods The study included 209 consecutive patients with APE (106 male, 103 female, mean age 62.4 +/- 15.4 years) and 162 controls (86 male, 76 female) matched for age (60.5 +/- 14.3 years) and concomitant diseases. Contrast-enhanced spiral computerized tomography or ventilation-perfusion scintigraphy, echocardiography, and lower extremity venous Doppler ultrasound were performed on the patients with APE. D-dimer level, troponin, arterial blood gases, platelet count, and MPV were measured in serum. Results The MPV did not differ between the patients with APE and the controls (8.0 +/- 1.1 fL, 7.9 +/- 0.59 fL, p = 0.22). There were no significant differences in the value of MPV among the groups of patients with massive, submassive, and nonmassive PE (MPV: 8.3 +/- 0.9 fL, 8.1 +/- 1.0 fL, 7.9 +/- 1.1 fL, p = 0.08, respectively). The MPV was higher in non-survivors than survivors (8.6 +/- 1.1 vs. 7.9 +/- 1.1 fL, p = 0.02). There was a statistically weak correlation between MPV and mean pulmonary arterial pressure (r = 0.25, p < 0.001) and also between MPV and right ventricle diameter (r = 0.11, p = 0.045). Conclusions Our results suggest that a simple baseline determination of MPV at a single time point is not a reliable indicator to determine the severity of PE or for the diagnosis of APE, but it is possible that the MPV increases in nonsurvivors.en_US
dc.identifier.doi10.1007/s00508-013-0380-9
dc.identifier.endpage385en_US
dc.identifier.issn0043-5325
dc.identifier.issue13-14en_US
dc.identifier.pmid23807041en_US
dc.identifier.scopus2-s2.0-84880919194en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1007/s00508-013-0380-9
dc.identifier.urihttps://hdl.handle.net/11616/96158
dc.identifier.volume125en_US
dc.identifier.wosWOS:000323673200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofWiener Klinische Wochenschriften_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean platelet volumeen_US
dc.subjectPlatelet activationen_US
dc.subjectPulmonary embolismen_US
dc.titleDoes the mean platelet volume have any importance in patients with acute pulmonary embolism?en_US
dc.typeArticleen_US

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