The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKorkmaz, Mehmet Fatih/0000-0001-7498-6763
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidceylan, mehmet fethi/ABF-1126-2020
dc.authorwosidKorkmaz, Mehmet Fatih/AAE-6018-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorKorkmaz, Mehmet Fatih
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorCeylan, Mehmet Fethi
dc.contributor.authorEdiz, Levent
dc.contributor.authorSamdanci, Emine
dc.contributor.authorKekilli, Ersoy
dc.contributor.authorSagir, Mustafa
dc.date.accessioned2024-08-04T20:09:49Z
dc.date.available2024-08-04T20:09:49Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Severe functional and anatomical defects can be detected after the peripheral nerve injury. Pharmacological approaches are preferred rather than surgical treatment in the treatment of nerve injuries. Aims: The aim of this study is to perform histopathological, functional and bone densitometry examinations of the effects of sildenafil on nerve regeneration in a rat model of peripheral nerve crush injury. Study Design: Animal experiment. Methods: The study included a total of thirty adult Sprague-Dawley rats that were divided into three groups of ten rats each. In all rats, a crush injury was created by clamping the right sciatic nerve for one minute. One day before the procedure, rats in group 1 were started on a 28-day treatment consisting of a daily dose of 20 mg/kg body weight sildenafil citrate given orally via a nasogastric tube, while the rats in group 2 were started on an every-other-day dose of 10 mg/kg body weight sildenafil citrate. Rats from group 3 were not administered any drugs. Forty-two days after the nerve damage was created, functional and histopathological examination of both sciatic nerves and bone densitometric evaluation of the extremities were conducted. Results: During the rotarod test, rats from group 3 spent the least amount of time on the rod compared to the drug treatment groups at speeds of 20 rpm, 30 rpm and 40 rpm. In addition, the duration for which each animal could stay on the rod throughout the accelerod test significantly reduced in rats from group 3 compared to rats from groups 1 and 2 in the 4-min test. For the hot-plate latency time, there were no differences among the groups in either the basal level or after sciatic nerve injury. Moreover, there was no significant difference between the groups in terms of the static sciatic index ( SSI) on the 42nd day ( p=0.147). The amplitude was better evaluated in group 1 compared to the other two groups ( p<0.05). Under microscopic evaluation, we observed the greatest amount of nerve regeneration in group 1 and the lowest in group 3. However, this difference was not statistically significant. Moreover, there was no significant difference in the bone mineral density (BMD) levels among the groups. Conclusion: We believe that a daily single dose of sildenafil plays an important role in the treatment of sciatic nerve damage and bone healing and thus can be used as supportive clinical treatment.en_US
dc.identifier.doi10.5152/balkanmedj.2016.14701
dc.identifier.endpage211en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue2en_US
dc.identifier.pmid27403391en_US
dc.identifier.scopus2-s2.0-84963632084en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage204en_US
dc.identifier.trdizinid208504en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2016.14701
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/208504
dc.identifier.urihttps://hdl.handle.net/11616/92454
dc.identifier.volume33en_US
dc.identifier.wosWOS:000375056600013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone densityen_US
dc.subjectperipheral nerve injuriesen_US
dc.subjectrotarod testen_US
dc.subjectsildenafilen_US
dc.subjectsciatic nerveen_US
dc.titleThe Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Ratsen_US
dc.typeArticleen_US

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