Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kluwer Academic/Plenum Publ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.
Açıklama
Anahtar Kelimeler
caffeic acid phenethyl ester, seizure, oxidative damage, brain
Kaynak
Neurochemical Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
29
Sayı
12
