Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice

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dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.contributor.authorIlhan, A
dc.contributor.authorIraz, M
dc.contributor.authorGurel, A
dc.contributor.authorArmutcu, F
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:39Z
dc.date.available2024-08-04T20:13:39Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSince overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.en_US
dc.identifier.doi10.1007/s11064-004-7038-y
dc.identifier.endpage2292en_US
dc.identifier.issn0364-3190
dc.identifier.issue12en_US
dc.identifier.pmid15672552en_US
dc.identifier.scopus2-s2.0-11144276531en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2287en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-004-7038-y
dc.identifier.urihttps://hdl.handle.net/11616/93769
dc.identifier.volume29en_US
dc.identifier.wosWOS:000225573500014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKluwer Academic/Plenum Publen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectseizureen_US
dc.subjectoxidative damageen_US
dc.subjectbrainen_US
dc.titleCaffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in miceen_US
dc.typeArticleen_US

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