Subclinical hypoxia of infants with intrauterine growth retardation determined by increased serum S100B protein levels

Basit Öğe Kaydı
dc.authoridBiçer, cemile/0000-0001-7937-4475
dc.authoridTatli, Mustafa Mansur/0000-0003-2767-3734
dc.authorwosidUras, Nurdan/AAR-5383-2020
dc.authorwosidbiçer, cemile/HQZ-5043-2023
dc.authorwosidTatli, Mansur M/E-6160-2016
dc.authorwosidBiçer, cemile/HJZ-2656-2023
dc.contributor.authorKirmemis, Ozlem
dc.contributor.authorTatli, Mustafa Mansur
dc.contributor.authorTayman, Cuneyt
dc.contributor.authorKoca, Cemile
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorUras, Nurdan
dc.contributor.authorDilmen, Ugur
dc.date.accessioned2024-08-04T21:02:25Z
dc.date.available2024-08-04T21:02:25Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: To test the hypothesis that serum S100B levels could be useful in detecting neurological damage in infants with intrauterine growth retardation (IUGR). Materials and methods: The study group consisted of infants with IUGR and the control group consisted of age-matched healthy infants. S100B protein levels were measured after birth and compared between groups. Results: For this study, 43 infants with IUGR and 25 infants as a control group were recruited. Gender, gestational age, type of delivery, and maternal age of the groups were statistically insignificant, with the exception of the mean birth weights (2120 +/- 450 g in the IUGR group and 3096 +/- 570 g in the control group (P < 0.001), respectively). S100B protein levels of the IUGR infants (1.13 +/- 0.54) were significantly higher than those of the control group (0.45 +/- 0.13) (P < 0.001). IUGR infants treated with antenatal steroids showed lower S100B levels than IUGR infants that did not receive antenatal steroid treatments (P < 0.05). The study group infants were divided into 2 groups, for growth retardation (GR) that was asymmetric (n = 15) and symmetric (n = 28). The asymmetric and symmetric GR infants' S100B levels were 1.14 +/- 0.47 pg/mL and 1.21 +/- 0.34 pg/mL, respectively, and no significant differences were found between the 2 groups in terms of S100B levels (P = 0.32). Conclusion: The results of this study favor the opinion that there is an existing intrauterine hypoxia causing hypoxic brain tissue damage in IUGR infants, even when followed up with modern obstetrical screening protocols. Measurements of S100B may be useful in the prediction of outcome in these infants.en_US
dc.identifier.doi10.3906/sag-1007-948
dc.identifier.endpage800en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-80051707401en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage795en_US
dc.identifier.trdizinid123244en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1007-948
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/123244
dc.identifier.urihttps://hdl.handle.net/11616/104742
dc.identifier.volume41en_US
dc.identifier.wosWOS:000295498300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectS100Ben_US
dc.subjectIUGRen_US
dc.subjectintrauterine growth retardationen_US
dc.subjectintrauterine hypoxiaen_US
dc.titleSubclinical hypoxia of infants with intrauterine growth retardation determined by increased serum S100B protein levelsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu