Synthesis and antimicrobial activity of electron rich olefin derived cyclic ureas
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ecv-Editio Cantor Verlag Medizin Naturwissenschaften
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Seventeen cyclic ureas containing imidazolidine and benzimidazoline nuclei were synthesised by the reaction of electron-rich olefins with appropriate group 16 elements (O, S, Se, Te). The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC) 25922) and Pseudomonas aeruginosa (ATCC 27853). Eight of the compounds were found effective to inhibit the growth of Gram-positive bacteria (Enterococcus Faecalis and Staphylococcus aureus) at MIC values between 25-400 mu g/ml. None of the compounds exhibit antimicrobial activity against gram-negative bacteria (Escherichia coli; and Pseudmonas aeruginosa) at the concentrations studied (6.25-800 mu g/ml).
Açıklama
Anahtar Kelimeler
antibiotics, benzimidazole derivatives, imidazole derivatives, urea derivatives, antimicrobial activity, cyclic
Kaynak
Arzneimittel-Forschung/Drug Research
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
46
Sayı
12
