Synthesis and antimicrobial activity of electron rich olefin derived cyclic ureas

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authoridCetinkaya, Bekir/0000-0002-4551-8650
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorCetinkaya, B
dc.contributor.authorCetinkaya, E
dc.contributor.authorKucukbay, H
dc.contributor.authorDurmaz, R
dc.date.accessioned2024-08-04T20:11:51Z
dc.date.available2024-08-04T20:11:51Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSeventeen cyclic ureas containing imidazolidine and benzimidazoline nuclei were synthesised by the reaction of electron-rich olefins with appropriate group 16 elements (O, S, Se, Te). The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC) 25922) and Pseudomonas aeruginosa (ATCC 27853). Eight of the compounds were found effective to inhibit the growth of Gram-positive bacteria (Enterococcus Faecalis and Staphylococcus aureus) at MIC values between 25-400 mu g/ml. None of the compounds exhibit antimicrobial activity against gram-negative bacteria (Escherichia coli; and Pseudmonas aeruginosa) at the concentrations studied (6.25-800 mu g/ml).en_US
dc.identifier.endpage1158en_US
dc.identifier.issn0004-4172
dc.identifier.issue12en_US
dc.identifier.pmid9006791en_US
dc.identifier.scopus2-s2.0-0030479525en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1154en_US
dc.identifier.urihttps://hdl.handle.net/11616/93048
dc.identifier.volume46en_US
dc.identifier.wosWOS:A1996WB49500011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibioticsen_US
dc.subjectbenzimidazole derivativesen_US
dc.subjectimidazole derivativesen_US
dc.subjecturea derivatives, antimicrobial activity, cyclicen_US
dc.titleSynthesis and antimicrobial activity of electron rich olefin derived cyclic ureasen_US
dc.typeArticleen_US

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