The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats

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dc.authoridSeven, Pınar Tatlı/0000-0002-0067-4190
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridGul, Burcu/0000-0002-9122-8953
dc.authorwosidSeven, Pınar Tatlı/W-3676-2017
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidGul, Burcu/V-9452-2018
dc.contributor.authorTatli Seven, Pinar
dc.contributor.authorGul Baykalir, Burcu
dc.contributor.authorParlak Ak, Tuba
dc.contributor.authorSeven, Ismail
dc.contributor.authorBasak, Nese
dc.contributor.authorYaman, Mine
dc.date.accessioned2024-08-04T20:09:57Z
dc.date.available2024-08-04T20:09:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P < 0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-alpha levels (P < 0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P < 0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.en_US
dc.identifier.doi10.1501/Vetfak_0000002873
dc.identifier.endpage406en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85055677343en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage395en_US
dc.identifier.trdizinid315020en_US
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002873
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/315020
dc.identifier.urihttps://hdl.handle.net/11616/92512
dc.identifier.volume65en_US
dc.identifier.wosWOS:000452407200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant statusen_US
dc.subjectcopperen_US
dc.subjectflunixin meglumineen_US
dc.subjecthistological changesen_US
dc.subjectpropolisen_US
dc.titleThe protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in ratsen_US
dc.typeArticleen_US

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