Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study

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dc.authoridSözen, Mustafa Mert/0000-0002-1672-2206
dc.authorwosidSözen, Mustafa Mert/E-7278-2011
dc.contributor.authorSozen, Mustafa Mert
dc.contributor.authorKartalci, Sukru
dc.date.accessioned2024-08-04T20:10:22Z
dc.date.available2024-08-04T20:10:22Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs.Methods: We genotyped 4 SNPs in a sample consisting of 302 SZ patients and 333 controls from a local Turkish population. We tested the disease associations of these variants at single SNP, haplotype and diplotype levels in case-control design.Results: At single SNP level, the CC genotype of rs3757930 was associated with SZ (p=0.038). The previously reported association of G-C haplotype in rs6988339-rs3757930 frame was absent (p=0.416), but we found another haplotype (C-G in rs3757930-rs74942016, p=0.018) and three diplotypes (A-C/G-C diplotype of rs6988339-rs3757930 frame, C-G/C-G diplotype of rs3757930-rs74942016 frame, and A-C-G/G-C-G diplotype of rs6988339-rs3757930-rs74942016 frame) associated with schizophrenia in our sample.Conclusions: Our study indicated the associations of a SNP, a haplotype, and a diplotype of NRG1 with schizophrenia and supported the involvement of NRG1 gene in the development of the disease. Since our sample was collected from a limited geographic area, the associations we have reported need to be supported by further studies in different populations.en_US
dc.description.sponsorshipThe Unit of Scientific Research Projects at Inonu University; [FOA-2020-2085]en_US
dc.description.sponsorshipThis study was supported by The Unit of Scientific Research Projects at Inonu University. Number of Project: FOA-2020-2085 to Mustafa Mert Soezen. All genetic analyses of patients and healthy volunteers have been founded with the project mentioned above.en_US
dc.identifier.doi10.1515/tjb-2022-0233
dc.identifier.endpage256en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85168370668en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage246en_US
dc.identifier.trdizinid1251839en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0233
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1251839
dc.identifier.urihttps://hdl.handle.net/11616/92740
dc.identifier.volume48en_US
dc.identifier.wosWOS:000994350000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectassociationen_US
dc.subjectdiplotypeen_US
dc.subjectgenetic associationen_US
dc.subjectgeneticsen_US
dc.subjecthaplotypeen_US
dc.subjectneuregulin-1en_US
dc.subjectNRG1en_US
dc.subjectschizophreniaen_US
dc.subjectSNPen_US
dc.titleAssociation of a haplotype in the NRG1 gene with schizophrenia: a case-control studyen_US
dc.typeArticleen_US

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