Ultrastructure of human umbilical vessels in pre-eclampsia
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parthenon Publishing Group Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Our objective in this study was to investigate the ultrastructure of endothelial and muscle cells of human umbilical vessels in both normal and pre-eclamptic pregnancies. Methods: Ten umbilical cords from pre-eclamptic (36, 38 and 40 weeks) and four from normal pregnancies (40 weeks) were collected immediately after vaginal deliveries. Umbilical veins and arteries were isolated and fixed in phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 4 h and postfixed with 1% osmium tetroxide at 4°C for 2 h. The sections were embedded in Araldit CY 212. Ultrathin sections were stained with uranyl acetate, examined and photographed. Results: Human umbilical vessel endothelial cells showed ultrastructural changes in pre-eclamptic patients. Weibel-Palade bodies and some organelles such as rough endoplasmic reticulum were found in increased numbers in venous endothelial cells. Accumulations of granular material were detected under the venous endothelium. Conclusion: The endothelial and muscle cells of the umbilical vessels from pregnancies complicated by pre-eclampsia showed morphological changes.
Açıklama
Anahtar Kelimeler
Endothelial cells, Pre-eclampsia, Ultrastructure, Umbilical cord
Kaynak
Journal of Maternal-Fetal and Neonatal Medicine
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
12
Sayı
3
