Ultrastructure of human umbilical vessels in pre-eclampsia

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dc.authorscopusid24472880600
dc.authorscopusid57207522696
dc.authorscopusid7004301483
dc.contributor.authorÇetin A.
dc.contributor.authorKükner A.
dc.contributor.authorÖztürk F.
dc.date.accessioned2024-08-04T20:02:26Z
dc.date.available2024-08-04T20:02:26Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Our objective in this study was to investigate the ultrastructure of endothelial and muscle cells of human umbilical vessels in both normal and pre-eclamptic pregnancies. Methods: Ten umbilical cords from pre-eclamptic (36, 38 and 40 weeks) and four from normal pregnancies (40 weeks) were collected immediately after vaginal deliveries. Umbilical veins and arteries were isolated and fixed in phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 4 h and postfixed with 1% osmium tetroxide at 4°C for 2 h. The sections were embedded in Araldit CY 212. Ultrathin sections were stained with uranyl acetate, examined and photographed. Results: Human umbilical vessel endothelial cells showed ultrastructural changes in pre-eclamptic patients. Weibel-Palade bodies and some organelles such as rough endoplasmic reticulum were found in increased numbers in venous endothelial cells. Accumulations of granular material were detected under the venous endothelium. Conclusion: The endothelial and muscle cells of the umbilical vessels from pregnancies complicated by pre-eclampsia showed morphological changes.en_US
dc.identifier.doi10.1080/jmf.12.3.178.184
dc.identifier.endpage184en_US
dc.identifier.issn1476-7058
dc.identifier.issue3en_US
dc.identifier.pmid12530615en_US
dc.identifier.scopus2-s2.0-0036746810en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage178en_US
dc.identifier.urihttps://doi.org/10.1080/jmf.12.3.178.184
dc.identifier.urihttps://hdl.handle.net/11616/91685
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherParthenon Publishing Group Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial cellsen_US
dc.subjectPre-eclampsiaen_US
dc.subjectUltrastructureen_US
dc.subjectUmbilical corden_US
dc.titleUltrastructure of human umbilical vessels in pre-eclampsiaen_US
dc.typeArticleen_US

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