Investigation of Clonal Relationship Between Candida Parapsilosis and Candida Glabrata Strains Isolated from Blood Culture by Pulse Field Gel Electrophoresis

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dc.contributor.authorAlici, Ayse
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorYenisehirli, Gulgun
dc.contributor.authorOtlu, Baris
dc.date.accessioned2026-04-04T13:30:50Z
dc.date.available2026-04-04T13:30:50Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractAim: Candidemia may occur when endogenous Candida species in the intestinal microbiota enter the bloodstream in patients with risk factors. Apart from endogenous transmission, patients can also transmit it exogenously. In the current study, we aimed to investigate the fluconazole susceptibility and genotypes of Candida parapsilosis (C.parapsilosis) and Candida glabrata (C. glabrata) strains that cause candidemia. Methods: Twenty-six C. parapsilosis and sixteen C. glabrata strains were included in the study. Fluconazole sensitivity was determined by the broth microdilution method. Genotyping of strains was done by pulsed-field gel electrophoresis. Results: Nine (34%) of C. parapsilosis strains and 3 (19%) of C. glabrata strains were found to be resistant to fluconazole. Among 26 C. parapsilosis isolates, 17 different genotypes were detected and clustered isolates were collected in five clusters. Fourteen out of the 26 C. parapsilosis isolates are placed in one of the clusters, with a clustering rate of 53.8%. Among 16 C. glabrata isolates, 11 different genotypes were detected and divided into four clusters. Nine out of the 16 C. glabrata isolates are placed in one of the clusters, with a clustering rate of 56.2%. Conclusion: Our data indicated the possibility of nosocomial transmission of C. parapsilosis and C. glabrata among intensive care unit patients in our hospital. Infection control policies should be strictly applied in our hospital to prevent cross-transmission.
dc.identifier.doi10.4274/haseki.galenos.2025.36844
dc.identifier.endpage68
dc.identifier.issn1302-0072
dc.identifier.issn2147-2688
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105008136336
dc.identifier.scopusqualityQ3
dc.identifier.startpage62
dc.identifier.trdizinid1325893
dc.identifier.urihttps://doi.org/10.4274/haseki.galenos.2025.36844
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1325893
dc.identifier.urihttps://hdl.handle.net/11616/108411
dc.identifier.volume63
dc.identifier.wosWOS:001506848200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofHaseki Tip Bulteni-Medical Bulletin of Haseki
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCandida parapsilosis
dc.subjectCandida glabrata
dc.subjectfluconazole susceptibility
dc.subjectgenotype
dc.titleInvestigation of Clonal Relationship Between Candida Parapsilosis and Candida Glabrata Strains Isolated from Blood Culture by Pulse Field Gel Electrophoresis
dc.typeArticle

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