Synthesis of some benzimidazole derivatives and their antibacterial and antifungal activities
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chemical Publishing Co.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A number of new benzimidazole derivatives were synthesized by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesized were identified by 1H NMR, 13C NMR, FT-IR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains i.e., Enterococcusfaecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the yeasts Candida albicans and Candida tropicalis. Some of the compounds were found effective to inhibit the growth of Gram positive (Efaecalis and S. aureus) at MIC values between 50-400 ?g/mL. None of the compounds exhibit antimicrobial activity against Gram negative bactreria (£. coli and P. aeruginosa) at the concentrations studied (6.25-800 ?g/mL). Nine of the tested compounds showed antifungal activity with a range of the MICs between 50 and 400 ?g/mL. © 2009 by Mrs. Pushpa Agarwal, Managing Editor, Asian Journal of Chemistry, Sahibabad, India.
Açıklama
Anahtar Kelimeler
Antibacterial activities, Antifungal activities, Benzimidazole derivatives, In vitro studies
Kaynak
Asian Journal of Chemistry
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
21
Sayı
8
