Synthesis of some benzimidazole derivatives and their antibacterial and antifungal activities

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dc.authorscopusid6701563510
dc.authorscopusid34768202700
dc.authorscopusid34768944300
dc.authorscopusid34767982400
dc.contributor.authorKüçükbay H.
dc.contributor.authorDurmazt R.
dc.contributor.authorSirecitt N.
dc.contributor.authorGünalt S.
dc.date.accessioned2024-08-04T19:59:38Z
dc.date.available2024-08-04T19:59:38Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA number of new benzimidazole derivatives were synthesized by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesized were identified by 1H NMR, 13C NMR, FT-IR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains i.e., Enterococcusfaecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the yeasts Candida albicans and Candida tropicalis. Some of the compounds were found effective to inhibit the growth of Gram positive (Efaecalis and S. aureus) at MIC values between 50-400 ?g/mL. None of the compounds exhibit antimicrobial activity against Gram negative bactreria (£. coli and P. aeruginosa) at the concentrations studied (6.25-800 ?g/mL). Nine of the tested compounds showed antifungal activity with a range of the MICs between 50 and 400 ?g/mL. © 2009 by Mrs. Pushpa Agarwal, Managing Editor, Asian Journal of Chemistry, Sahibabad, India.en_US
dc.identifier.endpage6189en_US
dc.identifier.issn0970-7077
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-68749101802en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage6181en_US
dc.identifier.urihttps://hdl.handle.net/11616/90759
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChemical Publishing Co.en_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activitiesen_US
dc.subjectAntifungal activitiesen_US
dc.subjectBenzimidazole derivativesen_US
dc.subjectIn vitro studiesen_US
dc.titleSynthesis of some benzimidazole derivatives and their antibacterial and antifungal activitiesen_US
dc.typeArticleen_US

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