Parameters Predicting Microvascular Invasion and Poor Differentiation in Hepatocellular Carcinoma Patients with Normal Alpha-fetoprotein Level Before Liver Transplantation

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridKilci, Mahmut Burak/0000-0001-9461-5222
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorKilci, Burak M.
dc.contributor.authorInce, Volkan
dc.contributor.authorCarr, Brian I.
dc.contributor.authorUsta, Sertac
dc.contributor.authorBag, Harika G.
dc.contributor.authorSamdanci, Emine
dc.contributor.authorIsik, Burak
dc.date.accessioned2024-08-04T20:10:21Z
dc.date.available2024-08-04T20:10:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: The aim of this study is to evaluate the parameters that might be associated with pathologically diagnosed microvascular invasion and poor differentiation, using complete blood count and routine clinical biochemistry test results, in hepatocellular carcinoma patients before liver transplantation. Materials and Methods: The data of patients who underwent liver transplantation for hepatocellular carcinoma at our institute, between March 2006 and November 2021, was researched retrospectively. Results: The incidence of microvascular invasion was 28.6%, poor differentiation rate was 9.3%, hepatocellular carcinoma recurrence rate after liver transplantation was 12.1%, and median time to recurrence was 13 months, in the patients with normal alpha-fetoprotein levels. After univariate and multivariate analysis, maximum tumor diameter >4.5 cm and the number of nodules (n > 5) were found to be independent risk factors for microvascular invasion, and number of nodules >4 and mean platelet volume =8.6 fL were found to be independent risk factors for poor differentiation. Serum alpha-fetoprotein levels were still within the normal range at the recurrence time, in 53% of the patients who had recurrence after liver transplantation, but surprisingly were elevated in 47% of the patients at time of hepatocellular carcinoma recurrence. Conclusion: In hepatocellular carcinoma patients with normal alpha-fetoprotein levels before liver transplantation, independent risk factors of the presence of microvascular invasion were maximum tumor diameter and number of nodules, and independent risk factors of poor differentiation were mean platelet volume and number of nodules. Furthermore, serum alpha-fetoprotein levels were still normal at time of recurrence in 53% of hepatocellular carcinoma patients whose alpha-fetoprotein levels were normal before liver transplantation but were elevated in 47% of the patients at recurrence time, despite having normal levels before liver transplantation.en_US
dc.identifier.doi10.5152/tjg.2023.22538
dc.identifier.endpage759en_US
dc.identifier.issn2148-5607
dc.identifier.issue7en_US
dc.identifier.pmid37326153en_US
dc.identifier.scopus2-s2.0-85164244858en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage753en_US
dc.identifier.trdizinid1188044en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2023.22538
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1188044
dc.identifier.urihttps://hdl.handle.net/11616/92729
dc.identifier.volume34en_US
dc.identifier.wosWOS:001037640200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNegative alpha-fetoproteinen_US
dc.subjecthepatocellular canceren_US
dc.subjectmicroscopic venous invasionen_US
dc.subjectmean platelet volumeen_US
dc.subjectpoorly differentiationen_US
dc.subjectliver transplantationen_US
dc.titleParameters Predicting Microvascular Invasion and Poor Differentiation in Hepatocellular Carcinoma Patients with Normal Alpha-fetoprotein Level Before Liver Transplantationen_US
dc.typeArticleen_US

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