Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
2,3,7,8-Tetracholorodibenzo-p-dioxin (TCDD) is a highly toxic environmental contaminant that causes severe toxic effects in animal and human. In this study, we investigated the toxic effects of TCDD and the preventive effects of protocatechuic acid (PCA), a widespread phenolic compound, in the heart tissue of rats. For this purpose, 3-4 months old 28 rats with 280-310g body weights were equally divided into 4 groups (control, TCDD, PCA, TCDD+PCA group). A 2g/kg dose of 2,3,7,8-TCDD and 100mg/kg dose of PCA were dissolved in corn oil and given orally to the rats for 45 days. The results indicated that TCDD induced oxidative stress by increasing the level of thiobarbituric acid reactive substance and by decreasing the levels of glutathione, catalase, glutathione peroxidase and superoxide dismutase in the heart tissue of rats. In contrast, PCA treatment prevents the toxic effects of TCDD on oxidative stress. In addition, histopathological alterations such as necrosis and hemorrhage occurred in TCDD group, and PCA treatment partially prevents these alterations in heart tissue. In this study, it was concluded that TCDD exposure led to toxic effects in heart tissue and PCA treatment could prevent the toxicity of TCDD.
Açıklama
Anahtar Kelimeler
2,3,7,8-TCDD, protocatechuic acid, cardiotoxicity, oxidative stress, rats
Kaynak
Toxicology and Industrial Health
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
29
Sayı
9
