Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats

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dc.authoriddisli, olcay murat/0000-0002-9699-4817
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridTimurkaan, Necati/0000-0001-5567-991X
dc.authorwosiddisli, olcay murat/ABI-3289-2020
dc.authorwosidTimurkaan, Necati/V-7016-2018
dc.contributor.authorCiftci, Osman
dc.contributor.authorDisli, Olcay Murat
dc.contributor.authorTimurkaan, Necati
dc.date.accessioned2024-08-04T20:37:52Z
dc.date.available2024-08-04T20:37:52Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetracholorodibenzo-p-dioxin (TCDD) is a highly toxic environmental contaminant that causes severe toxic effects in animal and human. In this study, we investigated the toxic effects of TCDD and the preventive effects of protocatechuic acid (PCA), a widespread phenolic compound, in the heart tissue of rats. For this purpose, 3-4 months old 28 rats with 280-310g body weights were equally divided into 4 groups (control, TCDD, PCA, TCDD+PCA group). A 2g/kg dose of 2,3,7,8-TCDD and 100mg/kg dose of PCA were dissolved in corn oil and given orally to the rats for 45 days. The results indicated that TCDD induced oxidative stress by increasing the level of thiobarbituric acid reactive substance and by decreasing the levels of glutathione, catalase, glutathione peroxidase and superoxide dismutase in the heart tissue of rats. In contrast, PCA treatment prevents the toxic effects of TCDD on oxidative stress. In addition, histopathological alterations such as necrosis and hemorrhage occurred in TCDD group, and PCA treatment partially prevents these alterations in heart tissue. In this study, it was concluded that TCDD exposure led to toxic effects in heart tissue and PCA treatment could prevent the toxicity of TCDD.en_US
dc.identifier.doi10.1177/0748233712442735
dc.identifier.endpage811en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid22495517en_US
dc.identifier.scopus2-s2.0-84885168179en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage806en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712442735
dc.identifier.urihttps://hdl.handle.net/11616/96229
dc.identifier.volume29en_US
dc.identifier.wosWOS:000329489600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,3,7,8-TCDDen_US
dc.subjectprotocatechuic aciden_US
dc.subjectcardiotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.titleProtective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of ratsen_US
dc.typeArticleen_US

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