EVALUATION OF THE EFFICACY OF SYSTEMICALLY APPLIED DENOSUMAB IN THE REPAIR OF BONE DEFECTS

Basit Öğe Kaydı
dc.contributor.authorPirinç, Ömer
dc.contributor.authorAlan, Hilal
dc.contributor.authorGül, Mehmet
dc.contributor.authorÇetiner, Yunus
dc.date.accessioned2026-04-04T13:19:07Z
dc.date.available2026-04-04T13:19:07Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study investigated the effect of denosumab on new bone formation, both alone and in combination with different graft materials. To this end, four defects were created in the skulls of 20 New Zealand rabbits. One defect was left empty, while the other three were treated with autograft, xenograft, and calcium phosphate (BCP) grafts. The animals were divided into an experimental group (n=10), which received 10 mg/kg of denosumab subcutaneously once a month for 2 months, and a control group (n=10), which was administered the same dose of physiological saline. After 8 weeks, the animals were sacrificed, and their bone tissue samples were analyzed histomorphometrically. The percentage of bone volume (PBV) was calculated by dividing the area of mature bone tissue by the total tissue area. The PBV in empty defects treated with denosumab was significantly higher than in the control group (p < 0.05). Moreover, the combination of denosumab and autograft resulted in a significant increase in new bone formation (NBF) (p < 0.05), thus demonstrating the positive effect of denosumab on bone formation. However, further research with larger experimental groups would be needed to determine the practicality, dosage, and duration of this treatment before clinical application. © 2025, Inonu University. All rights reserved.
dc.description.sponsorshipScientific Research Projects Unit of İnonuUniversity; İnönü Üniversitesi, INU, (2013/184)
dc.identifier.doi10.33715/inonusaglik.1568184
dc.identifier.endpage280
dc.identifier.issn2147-7892
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105009377439
dc.identifier.scopusqualityQ4
dc.identifier.startpage265
dc.identifier.trdizinid1321157
dc.identifier.urihttps://doi.org/10.33715/inonusaglik.1568184
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1321157
dc.identifier.urihttps://hdl.handle.net/11616/108167
dc.identifier.volume13
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherInonu University
dc.relation.ispartofJournal of Inonu University Vocational School of Health Services
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectAutograft
dc.subjectBiphasic calcium phosphate
dc.subjectCalvarial defect
dc.subjectDenosumab
dc.subjectXenograft
dc.titleEVALUATION OF THE EFFICACY OF SYSTEMICALLY APPLIED DENOSUMAB IN THE REPAIR OF BONE DEFECTS
dc.title.alternativeSistemik Olarak Uygulanan Denosumab'ın Kemik Defektlerinin Onarımındaki Etkinliğinin Değerlendirilmesi]
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu