Correlation between corneal endothelial layer features and age-related macular degeneration severity

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dc.contributor.authorOzturk, Emrah
dc.contributor.authorCankaya, Cem
dc.contributor.authorYildizli, Yakup
dc.date.accessioned2026-04-04T13:37:28Z
dc.date.available2026-04-04T13:37:28Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractPurposeThis study aimed to investigate the relationship between corneal endothelial layer features and the severity of age-related macular degeneration (AMD).MethodsThe study included 119 patients, with 47 females and 72 males. Patients were categorized into four groups based on the AREDS grading system: no AMD (group 1), mild AMD (group 2), moderate AMD (group 3), and advanced AMD (group 4). Only the right eye of patients with both eyes suitable for the study was included. Corneal endothelial cell density (CD), coefficient of variation (CoV), hexagonal cell ratio (HEX), and central corneal thickness (CCT) were measured using specular microscopy (Konan Medical Inc., Nishinomiya, Japan).ResultsGroup 1 had 40 patients, group 2 had 27 patients, and groups 3 and 4 had 26 patients each. Significant differences were observed between the mean endothelial CD, CoV, and HEX values among the groups, while no significant difference was found in CCT values (p = 0.049, p = 0.002, p = 0.004, and p = 0.883, respectively). A mild negative correlation was observed between AMD severity and CD and HEX values, while a mild positive correlation was found between AMD severity and CoV.ConclusionIncreasing severity of AMD may negatively impact corneal endothelial layer values.
dc.identifier.doi10.1007/s10792-024-03271-x
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1
dc.identifier.orcid0000-0001-7275-351X
dc.identifier.orcid0000-0002-3590-3213
dc.identifier.orcid0000-0002-7716-0438
dc.identifier.pmid39122890
dc.identifier.scopus2-s2.0-85200781076
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10792-024-03271-x
dc.identifier.urihttps://hdl.handle.net/11616/109851
dc.identifier.volume44
dc.identifier.wosWOS:001288134500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAge-related macular degeneration
dc.subjectCataract
dc.subjectCorneal endothelium
dc.subjectSpecular microscopy
dc.titleCorrelation between corneal endothelial layer features and age-related macular degeneration severity
dc.typeArticle

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