Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method

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dc.authoridFilazi, Ayhan/0000-0002-2800-6215
dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authorwosidFilazi, Ayhan/AAA-7163-2019
dc.authorwosidPezik, Esra/JCN-4721-2023
dc.authorwosidOzturk, Naile/F-3650-2017
dc.contributor.authorGultekin, Yakup
dc.contributor.authorOzturk, Naile
dc.contributor.authorFilazi, Ayhan
dc.contributor.authorDeniz, Ahmet
dc.contributor.authorKorkmaz, Cagla
dc.contributor.authorPezik, Esra
dc.contributor.authorBarin, Gozde
dc.date.accessioned2024-08-04T20:10:15Z
dc.date.available2024-08-04T20:10:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA simple, rapid and reproducible HPLC method has been developed and validated for the quantification of albendazole sulfoxide (ALBSOX) and praziquantel (PRZ), which can coexist in various dosage forms. Chromatographic separation was performed in gradient mode using a mobile phase consisting of an InertSustain (R) C18 column (150 x 4.6 mm, 5 mu m) and acetonitrile: water (v/v) at a flow rate of 1.0 mL/min. The active substance peaks were well separated and detected by a DAD detector at 217 nm. The HPLC method was linear for ALBSOX and PRZ in the concentration range of 0.1-50 mu g/mL. Limit of detection (LOD) was found to be 0.01 mu g/mL for ALBSOX and 0.009 mu g/mL for PRZ. The limit of quantification (LOQ) was found to be 0.03 mu g/mL for ALBSOX and 0.027 mu g/mL for PRZ. The developed HPLC method was validated based on ICH guidelines for specificity, linearity, system suitability, precision and accuracy. The method was applied for simultaneous quantification and characterization studies of ALBSOX and PRA in PLGA nanoparticles.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination [Unit]; [TSA-2021-19166]en_US
dc.description.sponsorshipAcknowledgements: This study was supported by Hacettepe University Scientific Research Projects Coordination [Unit with grant number TSA-2021-19166] .en_US
dc.identifier.doi10.29228/jrp.252
dc.identifier.endpage1618en_US
dc.identifier.issn2630-6344
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85142139035en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1608en_US
dc.identifier.trdizinid1175948en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.252
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175948
dc.identifier.urihttps://hdl.handle.net/11616/92680
dc.identifier.volume26en_US
dc.identifier.wosWOS:000893010600008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbendazole sulfoxideen_US
dc.subjectHPLC methoden_US
dc.subjectnanoparticleen_US
dc.subjectpraziquantelen_US
dc.subjectvalidationen_US
dc.titleSimultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC methoden_US
dc.typeArticleen_US

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