Comparison of Sirolimus and Colchicine Treatment on the Development of Peritoneal Fibrozis in Rats Having Peritoneal Dialysis

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dc.authoridsagiroglu, gonul/0000-0002-1189-4973
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.authorwosidsagiroglu, gönül/AAB-4472-2021
dc.authorwosidSagiroglu, Gonul/ABH-1345-2021
dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorYagci, Mehmet A.
dc.contributor.authorYalta, Tulin
dc.contributor.authorSagiroglu, Gonul
dc.contributor.authorCopuroglu, Elif
dc.contributor.authorOguz, Serhat
dc.date.accessioned2024-08-04T20:09:47Z
dc.date.available2024-08-04T20:09:47Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Continuous ambulatory peritoneal dialysis is a successful treatment modality for patients with end-stage renal disease. Peritoneal fibrosis (PF) is the most critical complication of long-term peritoneal dialysis (PD). Aims: In our study, we aimed to compare the effects of colchicine and sirolimus on PF induced by hypertonic peritoneal dialysis solutions in rats. Study Design: Animal experiment. Methods: Twenty-four rats were randomly divided into three groups. The control group received an intraperitoneal injection (ip) of saline. The sirolimus group received the PD solution, plus 1.0 mg/kg/day Rapamune (R). The colchicine group received the PD solution ip plus 1.0 mg/kg/day of colchicine. Blood samples were taken to measure the serum levels of VEGF, TGF-beta, and TNF-alpha. Peritoneal tissue samples were taken for histopathological evaluation. Results: TGF-beta and TNF-alpha values in the sirolimus group were found to be statistically significantly lower than in the control and colchicine groups, but the differences between the control and colchicine groups were not statistically significant. No statistically significant differences were found between the groups regarding the VEGF values. Vascular neogenesis and peritoneal thickness were compared; the values in the sirolimus group were statistically reduced compared to the values in the control group. Mild fibrosis developed in 75% of all animals in the sirolimus group; there was no moderate or severe fibrosis observed. Fibrosis developed to varying degrees in 100% of the animals in the control and colchicine groups. Conclusion: The present study demonstrates that sirolimus might be beneficial for preventing or delaying the progression of PF and neoangiogenesis. These alterations in the peritoneal membrane may be connected with reduced TNF-alpha and TGF-beta levels. the control and colchicine groups, but the differences between the control and colchicine groups were not statistically significant. No statistically significant differences were found between the groups regarding the VEGF values. Vascular neogenesis and peritoneal thickness were compared; the values in the sirolimus group were statistically reduced compared to the values in the control group. Mild fibrosis developed in 75% of all animals in the sirolimus group; there was no moderate or severe fibrosis observed. Fibrosis developed to varying degrees in 100% of the animals in the control and colchicine groups. Conclusion: The present study demonstrates that sirolimus might be beneficial for preventing or delaying the progression of PF and neoangiogenesis. These alterations in the peritoneal membrane may be connected with reduced TNF-alpha and TGF-beta levels.en_US
dc.identifier.doi10.5152/balkanmedj.2015.15183
dc.identifier.endpage106en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid25759780en_US
dc.identifier.scopus2-s2.0-84922919708en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage101en_US
dc.identifier.trdizinid168061en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2015.15183
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/168061
dc.identifier.urihttps://hdl.handle.net/11616/92429
dc.identifier.volume32en_US
dc.identifier.wosWOS:000351489300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColchicineen_US
dc.subjectperitoneal dialysisen_US
dc.subjectperitoneal fibrosisen_US
dc.subjectsirolimusen_US
dc.titleComparison of Sirolimus and Colchicine Treatment on the Development of Peritoneal Fibrozis in Rats Having Peritoneal Dialysisen_US
dc.typeArticleen_US

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