Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, it was aimed to use pyrrole monomer and single-walled carbon nanotube (SWCNT) in the productionof modified electrodes, and to examine the electrochemical properties of these electrodes. Bulk electrolysis technique wasused for growing polypyrrole. The applicability of the polypyrrole and SWCNT-based electrodes was tested byelectrochemically detecting active substances such as levodopa (LD) and benserazide (BS) used in the treatment ofParkinson's disease. During the design and analysis phase of the modified electrode, many electroanalytical optimizationand validation parameters were examined. The developed modified electrode gave linear responses with DPV techniquein concentration ranges of 10 - 50 µM for LD and 10 - 50 µM for BS. In addition, limits of detection in these wide linearranges were obtained as very low. Limits of detection were calculated as 2.4 µM and 1.2 µM for LD and BS, respectively.In addition, the applicability of the designed electrode and method was tested in urine and drug samples. The selectivityof this electrode was carried out in placebo solutions containing the interfering species. It is advantageous that the drugactive ingredients are easily, selectively and quickly determined at this modified electrode in the presence of componentsthat affect the analysis. Eventually, very satisfactory results in terms of analytical performance and applicability havebeen achieved with the designed electrode
Açıklama
Anahtar Kelimeler
Kaynak
International Journal of Pure and Applied Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
1
