Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

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dc.contributor.authorSavan, Ebru Kuyumcu
dc.contributor.authorErdoğdu, Gamze
dc.date.accessioned2024-08-04T19:51:37Z
dc.date.available2024-08-04T19:51:37Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, it was aimed to use pyrrole monomer and single-walled carbon nanotube (SWCNT) in the productionof modified electrodes, and to examine the electrochemical properties of these electrodes. Bulk electrolysis technique wasused for growing polypyrrole. The applicability of the polypyrrole and SWCNT-based electrodes was tested byelectrochemically detecting active substances such as levodopa (LD) and benserazide (BS) used in the treatment ofParkinson's disease. During the design and analysis phase of the modified electrode, many electroanalytical optimizationand validation parameters were examined. The developed modified electrode gave linear responses with DPV techniquein concentration ranges of 10 - 50 µM for LD and 10 - 50 µM for BS. In addition, limits of detection in these wide linearranges were obtained as very low. Limits of detection were calculated as 2.4 µM and 1.2 µM for LD and BS, respectively.In addition, the applicability of the designed electrode and method was tested in urine and drug samples. The selectivityof this electrode was carried out in placebo solutions containing the interfering species. It is advantageous that the drugactive ingredients are easily, selectively and quickly determined at this modified electrode in the presence of componentsthat affect the analysis. Eventually, very satisfactory results in terms of analytical performance and applicability havebeen achieved with the designed electrodeen_US
dc.identifier.doi10.29132/ijpas.855881
dc.identifier.endpage218en_US
dc.identifier.issn2149-0910
dc.identifier.issue1en_US
dc.identifier.startpage207en_US
dc.identifier.trdizinid461028en_US
dc.identifier.urihttps://doi.org/10.29132/ijpas.855881
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/461028
dc.identifier.urihttps://hdl.handle.net/11616/89115
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Pure and Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleVoltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrodeen_US
dc.typeArticleen_US

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