Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells

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dc.authoridKul Koprulu, Tuğba/0000-0001-9451-5715
dc.authoridAKKOÇ, Mitat/0000-0001-8641-8958
dc.authoridPAŞAHAN, RAMAZAN/0000-0002-3221-1422;
dc.authorwosidKul Koprulu, Tuğba/HNI-6373-2023
dc.authorwosidAKKOÇ, Mitat/AAJ-5780-2020
dc.authorwosidPAŞAHAN, RAMAZAN/AAB-3576-2021
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.contributor.authorPasahan, Ramazan
dc.contributor.authorAkkoc, Mitat
dc.contributor.authorYasar, Seyma
dc.contributor.authorKul Koprulu, Tugba
dc.contributor.authorTekin, Saban
dc.contributor.authorYasar, Sedat
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:10:13Z
dc.date.available2024-08-04T20:10:13Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). The Ru(II)-NHC complexes (4a-h) were synthesized via transmetalation reaction from 3a-e. 4a-h complexes were converted to Ru(II)-NHC. HCl complexes (5a-h) by HCl solution of diethyl ether and characterized by different spectroscopic techniques such as H-1 and C-13 NMR, LC/MS-Q-TOF, FT-IR, elemental analysis, and melting point detection. We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay. The IC50 value of 5b, 5c and 5e complexes exhibited good cytotoxic activity than cisplatin on C6 (14.2 +/- 0.5 mM; 16.2 +/- 0.4 mM; 24.2 +/- 0.7 mM, respectively) and HeLa (11.1 +/- 0.5 mM; 13.7 +/- 0.3 mM; 22.8 +/- 0.8 mM, respectively) cell lines.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z036]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 114Z036).en_US
dc.identifier.doi10.55730/1300-0527.3418
dc.identifier.endpage+en_US
dc.identifier.issn1300-0527
dc.identifier.issue4en_US
dc.identifier.pmid37538752en_US
dc.identifier.scopus2-s2.0-85137389088en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1097en_US
dc.identifier.trdizinid1141986en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3418
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1141986
dc.identifier.urihttps://hdl.handle.net/11616/92669
dc.identifier.volume46en_US
dc.identifier.wosWOS:000895319000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC6en_US
dc.subjectHeLaen_US
dc.subjectantiproliferative activityen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectrutheniumen_US
dc.subjectsilveren_US
dc.titleSynthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cellsen_US
dc.typeArticleen_US

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