The effects of sugammadex on coagulation in pregnant rats

Basit Öğe Kaydı
dc.authorscopusid57222900498
dc.authorscopusid57214780643
dc.authorscopusid55898201200
dc.authorscopusid23488098800
dc.authorscopusid36157712500
dc.contributor.authorKeskin M.E.
dc.contributor.authorKaplan H.S.
dc.contributor.authorGülhas N.
dc.contributor.authorBayram Y.
dc.contributor.authorBasbugan Y.
dc.date.accessioned2024-08-04T20:01:11Z
dc.date.available2024-08-04T20:01:11Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSome studies have reported that sugammadex affects coagulation parameters. However, the effects of sugammadex on coagulation in pregnant women have not been adequately evaluated. This study investigated the effects of sugammadex administration on routine coagulation tests and levels of coagulation factors (FII, FV, FVII, FVIII, FIX, and FX) in pregnant rats. After ethics committee approval (2019/06), 24 female Wistar albino rats (n = 12; 19–20 days of gestation; weight 230–380 g) were randomly divided into four groups: control (n = 6), sugammadex (n = 6), pregnant (n = 6), and pregnant sugammadex (n = 6). Ketamine (50 mg/kg) and xylazine (10 mg/kg) were administered intraperitoneally to all groups. Saline (SF) (1 ml/kg) was administered to the control and pregnant groups. Sugammadex was administered to the sugammadex and pregnant sugammadex groups at a dose of 16 mg/kg. Blood samples were collected at 30 min after SF and sugammadex administration in all rats. The levels of PT, INR, aPTT, fibrinogen and coagulation factors were measured in plasma obtained from blood samples. All animals were sacrificed by cervical dislocation after the procedure. The mean weights of the rats were significantly higher in the pregnant groups (pregnant and pregnant sugammadex groups) than in the non-pregnant groups (control and sugammadex groups). The mean PT and INR values were significantly lower in the pregnant than non-pregnant groups. No significant differences were observed in any of the parameters evaluated between the sugammadex-and SF-administered groups. Sugammadex administration did not affect routine coagulation tests or the levels of coagulation factors in pregnant rats. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.en_US
dc.identifier.doi10.5505/ejm.2021.34711
dc.identifier.endpage298en_US
dc.identifier.issn1301-0883
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85104195346en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage294en_US
dc.identifier.trdizinid411980en_US
dc.identifier.urihttps://doi.org/10.5505/ejm.2021.34711
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/411980
dc.identifier.urihttps://hdl.handle.net/11616/91315
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood coagulation factorsen_US
dc.subjectBlood coagulation testsen_US
dc.subjectPregnancyen_US
dc.subjectRatsen_US
dc.subjectSugammadexen_US
dc.titleThe effects of sugammadex on coagulation in pregnant ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu