Synthesis of new anthraquinone compounds and evaluation of their considerable xanthine oxidase inhibitory activities
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Arkat Usa Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A series of anthraquinone derivatives (1-11) was prepared using alkyl halides, quinizarin, and danthron. The structural analysis of new compounds was carried out by 1H, 13C NMR, IR, and UV-Vis spectroscopic techniques. Xanthine oxidase inhibitory activities of compounds were measured using allopurinol as a standard. Inhibition abilities were identified by measuring the uric acid formation at 294 nm at 37 degrees C. According to the IC50 values of the compounds, it was observed that all the compounds in the group had higher inhibition values than allopurinol.
Açıklama
Anahtar Kelimeler
Anthraquinone derivative, quinizarin, danthron, xanthine oxidase, inhibition
Kaynak
Arkivoc
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
