TRP Channels in Tension-Type Headache: A Pilot Study

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dc.authoridTASCI, IREM/0000-0001-7069-769X
dc.authorwosidTASCI, IREM/AAW-3048-2020
dc.contributor.authorGemici, Yagmur Inalkac
dc.contributor.authorTasci, Irem
dc.contributor.authorDurmu, Kubra
dc.contributor.authorKoc, Ahmet
dc.date.accessioned2024-08-04T20:10:09Z
dc.date.available2024-08-04T20:10:09Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTension-type headache (TTH) affects many individuals worldwide. Although the exact pathogenesis of TTH remains unclear, central, and peripheral mechanisms are considered to play a role in TTH 1. This pilot study aimed to investigate the role of transient receptor potential (TRP) channels in the development or chronic inflammation in TTH and to discuss the findings in the light of literature. This pilot study included a patient group comprising three patients with episodic TTH and three patients with chronic TTH (CTTH) aged 18-40 years with no comorbidities and a control group of three patients with no headache. Peripheral blood samples were obtained from all the participants, and both RNA and cDNA were isolated on the same day. The mRNA levels of pain-related TRP channels [TRPA1, TRP vanilloid-1 (TRPV1), TRPV3, TRPV4, TRPM3, and TRPM8] were measured by reverse transcriptase (RT)-quantititave polymerase chain reaction method and were normalized with the levels of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) transcript. Results were analyzed using statistical methods. All three groups were comparable with regard to demographic characteristics. No significant difference was found among the groups with regard to the mRNA levels of the TRP channels normalized by GAPDH, whereas the TRPM8 expression levels were not significantly lower in the CTTH group than in other groups (p = 0.066). This study revealed that TRPM8 is likely to have a role in the pathogenesis of TTH, and this role of TRPM8 may be investigated by further studies.en_US
dc.identifier.doi10.4274/tnd.2021.26879
dc.identifier.endpage458en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85124935532en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage454en_US
dc.identifier.trdizinid506008en_US
dc.identifier.urihttps://doi.org/10.4274/tnd.2021.26879
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/506008
dc.identifier.urihttps://hdl.handle.net/11616/92627
dc.identifier.volume27en_US
dc.identifier.wosWOS:000740715600021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Neurological Socen_US
dc.relation.ispartofTurkish Journal of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTRP channelsen_US
dc.subjectstension-typeen_US
dc.subjectheadacheen_US
dc.titleTRP Channels in Tension-Type Headache: A Pilot Studyen_US
dc.typeArticleen_US

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