Antibacterial effectiveness of alkalinized ropivacaine and bupivacaine

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dc.authorscopusid8861779800
dc.authorscopusid55898201200
dc.authorscopusid55666804700
dc.authorscopusid7801413617
dc.authorscopusid56067103500
dc.authorscopusid53876140000
dc.contributor.authorBegeç Z.
dc.contributor.authorGülhaş N.
dc.contributor.authorToprak H.I.
dc.contributor.authorErdil F.
dc.contributor.authorYetkin G.
dc.contributor.authorÖzean Ersoy M.
dc.date.accessioned2024-08-04T20:02:10Z
dc.date.available2024-08-04T20:02:10Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: We aimed to investigate the antibacterial effects of alkalinized ropivacaine and bupivacaine on the Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa Materials and Methods: In this study, solutions of bupivacaine 0.5%, ropivaeaine 0.2%, bupivakain 0.5%+NaHCO3, ropivakain 0.2%+NaHCO3 with bactorial cultures' E. coli, S. aureus and P. aeruginosa were used. Bacteria were grown on standard blood agar. Bacterial cultures were prepared in a density of 0.5 McFarlands units (10 8 efu ml-1) with sterile saline 0.9% and each bacterial solution was further diluted in Mueller-Hinton broth to obtain standard inocula (105 cfu ml-1). The tested solutions (2 ml) and controls (2 ml, physiological saline) were added to 2 ml of standard bacterial preparations. Aliquats (3 ml) were vortexed and pipetted into sterile polystyrene spectrophotometer cuvets and it was incubated at 37°C. The optical density at 540 nm was measured at 0, 3 and 6 h by spectrophotometer. Results: While hupivacaine inhibited the growth of S. aureus and E. coli at all measurements times, P. aeruginosa inhibited at only 6 h (p<0.05). Alkalinized bupivacaine inhibited the growth of S. aureus at 0 h and E. coli at 0 and 6 h (p<0.05). Antibacterial effects of hupivacaine on E. coli was significantly higher than alkalinized bupivacaine at 6h (p<0.05). While ropivaeaine more inhibited the growth of S. aureus at 0 and 3 h than alkalinized ropivauaine, alkalinized ropivacaine less inhibited it according to the control (p<0.05). While both ropivacainc and alkalinized ropivakain inhibited the growth of E. coli at 3 and 6 h, at 0 h only ropivacaine inhibited it (p<0.05). Ropivacaine and alkalinized ropivaeaine inhibited the growth of P. aeruginosa at 3 h (p<0.05). Conclusion: It has been determined that bupivacaine has antibacterial effect and alkalinization of bupivacaine does not change it, ropivacaine has poor antibacterial effect and it more reduced with alkalinization of ropivacaine.en_US
dc.identifier.endpage15en_US
dc.identifier.issn1304-0871
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-34248673438en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://hdl.handle.net/11616/91446
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBupivacaineen_US
dc.subjectMicrobiological phenomenaen_US
dc.subjectRopivacaineen_US
dc.subjectSodium bicarbonateen_US
dc.titleAntibacterial effectiveness of alkalinized ropivacaine and bupivacaineen_US
dc.title.alternativeAlkalinize bupivakain ve ropivakainin antibakteriyel etkinli?ien_US
dc.typeArticleen_US

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