Evaluation of the diagnostic significance of some biomarkers in pruritic dermatological diseases: A case-control study

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dc.authorscopusid57211524435
dc.authorscopusid47562309000
dc.authorscopusid57222505412
dc.authorscopusid57216969832
dc.authorscopusid57223595144
dc.authorscopusid26024440900
dc.contributor.authorTürkmen N.B.
dc.contributor.authorTürkmen D.
dc.contributor.authorYüce H.
dc.contributor.authorMarsak M.
dc.contributor.authorTanriverdi Z.
dc.contributor.authorÜnüvar S.
dc.date.accessioned2024-08-04T20:00:55Z
dc.date.available2024-08-04T20:00:55Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Indolamine-2,3-dioxygenase (IDO), neopterin, periostin, tenascin-C (TN-C), chitinase-3-like protein 1 (CHI3L1/YKL-40) YKL-40 have been previously described as diagnostic markers for a number of pathologies. The aim of our study is to compare the levels of some immune system-related biomarkers in itchy dermatological diseases with healthy people and to evaluate the diagnostic importance of these markers in dermatological diseases. Material and Methods: Our study included 55 patients diagnosed with neurodermatitis, generalised pruritus and lichen planus. The control group was composed of 30 healthy adult volunteers with no history of allergic skin conditions. All participants provided informed consent for the use of their medical data in the study. The serum samples were centrifuged. Centrifuged samples were stored at -80 ?. IDO, neopterin, periostin, TN-C, YKL-40 levels were determined by an enzyme-linked immunosorbent assay. The Mann-Whitney U test, Kruskal-Wallis test, and Conover post-hoc method were used for statistical analysis. Results: Demographic characteristics were recorded and no statistically significant difference was found between demographic differences. IDO, neopterin, periostin, TN-C, YKL-40 levels were higher in patients than in controls (p<0.05). The Th1/Th2-mediated immune response activation has been observed in allergic skin diseases. A positive correlation was found between all measured parameters (p<0.01). Conclusion: In our study, non-invasive current biomarkers that can be used in the diagnosis of dermatological pathologies yielded significant results. We found higher levels of serum biomarkers in patients compared to controls. It remains uncertain whether the examined protein is related only to inflammation or is released also as a result of specific biochemical processes due to allergy. However, these indicators may still have an important place in terms of early diagnosis. Copyright © 2021 by Türkiye Klinikleri. This is an openen_US
dc.identifier.doi10.5336/dermato.2021-81122
dc.identifier.endpage92en_US
dc.identifier.issn1300-0330
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85113171518en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage86en_US
dc.identifier.trdizinid520004en_US
dc.identifier.urihttps://doi.org/10.5336/dermato.2021-81122
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/520004
dc.identifier.urihttps://hdl.handle.net/11616/91118
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherOrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.en_US
dc.relation.ispartofTurkiye Klinikleri Dermatolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3-dioxygenaseen_US
dc.subjectIndoleamine-2en_US
dc.subjectNeopterinen_US
dc.subjectPeriostinen_US
dc.subjectPruritic diseasesen_US
dc.subjectTenascin-Cen_US
dc.titleEvaluation of the diagnostic significance of some biomarkers in pruritic dermatological diseases: A case-control studyen_US
dc.title.alternativeKaşıntılı Dermatolojik Hastalıklarda Bazı Biyobelirteçlerin Tanısal Öneminin Değerlendirilmesi: Bir Vaka Kontrol Çalışmasıen_US
dc.typeArticleen_US

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