The Antioxidant Effect of Melatonin on Myocardial Ischemia Reperfusion Injury in Experimental Studies

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dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorÖrüm, Mehmet Hamdi
dc.date.accessioned2024-08-04T19:53:22Z
dc.date.available2024-08-04T19:53:22Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA lot of mechanisms play major role in the myocardial ischemia reperfusion injury (MI/R), especially reactive oxygen species (ROS) which they formed rapidly when molecular oxygen enters into the cell. Melatonin, major hormone of the pineal gland, has very strong antioxidant and free radical scavenger effects. Besides, melatonin plays an important role in the regulation of various body functions including circadien sleep rhythms, blood pressure, oncogenesis, retinal function, and immunity. It can be possible to say that oxidative stress occurs during MI/R and melatonin administration exerts an infarct size limiting effect, antiapoptic, antiarryhtmic effects and enhances antioxidant activity of the heart.en_US
dc.identifier.endpage1780en_US
dc.identifier.issn2147-0634
dc.identifier.issue4en_US
dc.identifier.startpage1766en_US
dc.identifier.trdizinid230837en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/230837
dc.identifier.urihttps://hdl.handle.net/11616/89727
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Antioxidant Effect of Melatonin on Myocardial Ischemia Reperfusion Injury in Experimental Studiesen_US
dc.typeReview Articleen_US

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