Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

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dc.authoridTağluk, M. Emin/0000-0001-7789-6376
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X;
dc.authorwosidTağluk, M. Emin/ABH-1005-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorTurhan, Ugur
dc.contributor.authorTagluk, Mehmet Emin
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:09:46Z
dc.date.available2024-08-04T20:09:46Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: In this experimental study, we aimed to investigate the role of melatonin on uterine myoelectrical activity of non-pregnant rats. Material and Methods: Forty-six female rats were assigned to six groups: (1) control; (0.2 mL 0.9% NaCl was injected intravenously (IV), n=6); (2) melatonin applied as 0.4 mg/kg/IV (n=8); (3) melatonin applied as 4 mg/kg/IV (n=8); (4) single dose of oxytocin (100 mU/kg) injected IV (n=8); (5) melatonin (0.4 mg/kg) plus oxytocin (100 mU/kg) (n=8); and (6) melatonin (4 mg/kg) plus oxytocin (100 mU/kg) injected IV (n=8). Each rat underwent a laparotomy, and uterine myoelectrical signals were recorded. The mean spectrum, averaged over the spectral content of signals in each group, was compared. Results: Melatonin induced uterine myoelectrical activity in a dose-dependent manner. Treatment of melatonin after oxytocin suppressed the mean power of the signals. Serum melatonin concentrations were significantly higher in melatonin-treated rats. Conclusion: Melatonin itself at two different dose levels was found to be equally effective in stimulating the uterine electrical signals, although oxytocin-induced uterine electrical activity was suppressed by melatonin. These findings merit further investigations on the possible beneficial role of melatonin in the treatment of conditions associated with abnormal uterine activity.en_US
dc.identifier.doi10.5152/jtgga.2014.26932
dc.identifier.endpage91en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue2en_US
dc.identifier.pmid24976773en_US
dc.identifier.scopus2-s2.0-84902462886en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage86en_US
dc.identifier.trdizinid159100en_US
dc.identifier.urihttps://doi.org/10.5152/jtgga.2014.26932
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/159100
dc.identifier.urihttps://hdl.handle.net/11616/92420
dc.identifier.volume15en_US
dc.identifier.wosWOS:000420674300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUterine contractionen_US
dc.subjectmelatoninen_US
dc.subjectoxytocinen_US
dc.subjectelectrical stimulationen_US
dc.titleDual effects of melatonin on uterine myoelectrical activity of non-pregnant ratsen_US
dc.typeArticleen_US

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