Evaluation of the effects of adipose-derived mesenchymal stem cells on intraperitoneal adhesions

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dc.authoridkaradağ, mehmet/0000-0001-9539-4193
dc.authoridkaradağ, mehmet/0000-0001-9539-4193
dc.authorwosidkaradağ, mehmet/AFE-8117-2022
dc.authorwosidkaradağ, mehmet/AAE-9646-2022
dc.contributor.authorUysal, Erdal
dc.contributor.authorDokur, Mehmet
dc.contributor.authorKirdak, Turkay
dc.contributor.authorKurt, Akif
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-08-04T20:09:57Z
dc.date.available2024-08-04T20:09:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The goal was to examine the efficiency of local implementation of adipose-derived mesenchymal stem cells, which have an anti-inflammatory effect, in preventing the intra-abdominal adhesions in rats. Material and Methods: Twenty-one Wistar albino rats were randomly divided into 3 groups, 7 rats in each: Group 1 was defined as the control group, Group 2 as the sham group, and Group 3 as the adipose-derived mesenchymal stem cell group. A 6 cm mid-abdomen incision in the all the rats was performed. The cecum serosa and sub-serosa were injured by rubbing with a gauze. No agent was applied intraperitoneally for the rats in Group 1; 1.5 mL saline and 2x106/ kg allojenic adipose-derived mesenchymal stem cells in the 1.5 mL saline were injected into peritoneum of rats in Groups 2 and 3, respectively. Laparotomy was performed on the 14th day. Adhesion scores, histopathological examination, E-cadherin expression, and the tissue hydroxyproline level were evaluated. Results: The general adhesion score and collagen deposition in Group 3 were found to be significantly higher than in Groups 1 and 2 (p=0.003 and p=0.009, respectively). In the inflammatory cell comparison, a significant decrease was found in Group 3 in proportion to Groups 1 and 2 (p=0.001, p=0.005, respectively). The E-cadherin levels were found to be higher in Group 3 (p=0.003). Conclusion: Severe adhesion was observed in the adipose-derived mesenchymal stem cells group. Collagen intensity and E-Cadherin expression also increased in the adipose-derived mesenchymal stem cells group. The anti-inflammatory effect was also seen in the adipose-derived mesenchymal stem cells group.en_US
dc.identifier.doi10.5152/turkjsurg.2017.3860
dc.identifier.endpage190en_US
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue3en_US
dc.identifier.pmid30216177en_US
dc.identifier.scopus2-s2.0-85054822025en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage184en_US
dc.identifier.trdizinid305730en_US
dc.identifier.urihttps://doi.org/10.5152/turkjsurg.2017.3860
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/305730
dc.identifier.urihttps://hdl.handle.net/11616/92510
dc.identifier.volume34en_US
dc.identifier.wosWOS:000446227800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectE-cadherinen_US
dc.subjectraten_US
dc.subjecthydroxyprolineen_US
dc.subjectperitoneal adhesionen_US
dc.subjectstem cellsen_US
dc.titleEvaluation of the effects of adipose-derived mesenchymal stem cells on intraperitoneal adhesionsen_US
dc.typeArticleen_US

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