Helicobacter pylori'ye bağlı gelişmiş çeşitli gastroduodenal patolojilerde lenfoid follikül ve intestinal metaplazi görülme sıklığı
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Gastroenterology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Bu çalışma ile Helicobacter pylori'ye (H. pylori) bağlı gelişmiş klinik olarak önemli çeşitli gastroduodenal patolojilerde lenfoid follikül ve intestinal metaplazi görülme sıklığı araştırıldı. Histolopatolojik olarak doğrulanmış H. pylori infeksiyonu olan 153 olgu (110 nonülser dispepsili, 23 duodenal ülserli, 20 obstrüksiyonla komplike duodenal ülserli) çalışmaya alındı. Olgulardan alınan mide biopsiler germinal merkezli lenfoid follikül ve intestinal metaplazi varlığı açısından değerlendirildi. Nonülser dispepsili olguların %44.5'inde, obstrüksiyonla komplike duodenal ülserli olguların %70'inde, komplikasyonsuz duodenal ülserli olguların % 47.8'inde bir veya daha fazla germinal merkezli lenfoid follikül saptandı. Nonülser dispepsili %15.5, komplike duodenal ülserli %20 olguda intestinal metaplazi saptanırken komplikasyonsuz duodenal ülserli olgularda intestinal metaplazi saptanmadı. Gastroduodenal patolojiler arasında intestinal metaplazi varlığı açısından istatiksel açıdan anlamlı farklılık saptanamazken (p>0.05), komplike duodenal ülserli olgularda nonülser dispepsili ve komplikasyonsuz dudenal ülserlilerden istatiksel açıdan anlamlı (p<0.05) daha yüksek oranda lenfoid follikül saptandı. Bu sonuç, obstrüksiyonla komplike duodenal ülserli olgulardaki H. pylori enfeksiyonunun diğer gastroduodenal patolojilerdeki H. pylori enfeksiyonuna göre nispeten daha kronik ve daha agresif bir enfeksiyon olduğunu düşündürmektedir.
Abstract: This study was designed to investigate the prevalence of lymphoid follicle formation and intestinal metaplasia in patients with Helicobacter pylori (H.pylori) associated clinically significant diseases. Biopsies from the antrum, corpus and fundus of stomach were obtained from 153 patients (non-ulcer dyspepsia, n: 110; duodenal ulcer n: 23, duodenal ulcer complicated by obstruction, n: 20) with histopathologically proven H. pylori infection. All biopsies were examined for lymphoid follicle with germinal center and intestinal metaplasia. Lymphoid follicles were found in 44.5% of nonulcer diyspeptic patients, 70% of duodenal ulcer complicated by obstruction patients and in 47.8% of uncomplicated duodenal ulcer patients. In contrast, 15.5% of non-ulcer disypeptic patients and 20% of complicated duodenal ulcer patients had associated intestinal metaplasia while no intestinal metaplasia was observed in uncomplicated duodenal ulcer patients. Intestinal metaplasia incidence was not statistically different among the different gastroduodenal pathologies (P>0.05). However the incidence of lymphoid follicles was significantly higher in patients with complicated duodenal ulcer (P<0.05). Our results indicate that H.pylori infection in complicated duodenal ulcers are relatively chronic and aggressive compared to H.pylori infection in other gastroduodenal disorders.
Abstract: This study was designed to investigate the prevalence of lymphoid follicle formation and intestinal metaplasia in patients with Helicobacter pylori (H.pylori) associated clinically significant diseases. Biopsies from the antrum, corpus and fundus of stomach were obtained from 153 patients (non-ulcer dyspepsia, n: 110; duodenal ulcer n: 23, duodenal ulcer complicated by obstruction, n: 20) with histopathologically proven H. pylori infection. All biopsies were examined for lymphoid follicle with germinal center and intestinal metaplasia. Lymphoid follicles were found in 44.5% of nonulcer diyspeptic patients, 70% of duodenal ulcer complicated by obstruction patients and in 47.8% of uncomplicated duodenal ulcer patients. In contrast, 15.5% of non-ulcer disypeptic patients and 20% of complicated duodenal ulcer patients had associated intestinal metaplasia while no intestinal metaplasia was observed in uncomplicated duodenal ulcer patients. Intestinal metaplasia incidence was not statistically different among the different gastroduodenal pathologies (P>0.05). However the incidence of lymphoid follicles was significantly higher in patients with complicated duodenal ulcer (P<0.05). Our results indicate that H.pylori infection in complicated duodenal ulcers are relatively chronic and aggressive compared to H.pylori infection in other gastroduodenal disorders.
Açıklama
Yıl: 1999Cilt: 10Sayı: 3ISSN: 1300-4948 / 2148-5607Sayfa Aralığı: 197 - 201Metin Dili:Türkçe
Anahtar Kelimeler
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
3
Künye
TAŞKIN V,GÜRER İ,SARI R,AYDIN A,YILDIRIM B,ALADAĞ M,HİLMİOĞLU F (1999). Helicobacter pylori'ye bağlı gelişmiş çeşitli gastroduodenal patolojilerde lenfoid follikül ve intestinal metaplazi görülme sıklığı. Turkish Journal of Gastroenterology, 10(3), 197 - 201.
