New coumarin derivatives as carbonic anhydrase inhibitors

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Taylor & Francis Ltd

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.

Açıklama

Anahtar Kelimeler

benzimidazolium, carbonic anhydrase, coumarin, imidazolium, inhibition

Kaynak

Artificial Cells Nanomedicine and Biotechnology

WoS Q Değeri

Q4

Scopus Q Değeri

Q1

Cilt

42

Sayı

3

Künye