New coumarin derivatives as carbonic anhydrase inhibitors

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dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridErgün, Adem/0000-0003-4647-6058
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidGençer, Nahit/HHD-1544-2022
dc.authorwosidGençer, Nahit/AAG-4507-2019
dc.authorwosidErgün, Adem/AAC-1751-2022
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorAlici, Bulent
dc.contributor.authorCakir, Umit
dc.contributor.authorCetinkaya, Engin
dc.contributor.authorDemir, Dudu
dc.contributor.authorErgun, Adem
dc.contributor.authorGencer, Nahit
dc.date.accessioned2024-08-04T20:39:42Z
dc.date.available2024-08-04T20:39:42Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.en_US
dc.identifier.doi10.3109/21691401.2013.794352
dc.identifier.endpage198en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue3en_US
dc.identifier.pmid23656671en_US
dc.identifier.scopus2-s2.0-84901012639en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2013.794352
dc.identifier.urihttps://hdl.handle.net/11616/96452
dc.identifier.volume42en_US
dc.identifier.wosWOS:000336498100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine and Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbenzimidazoliumen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectcoumarinen_US
dc.subjectimidazoliumen_US
dc.subjectinhibitionen_US
dc.titleNew coumarin derivatives as carbonic anhydrase inhibitorsen_US
dc.typeArticleen_US

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