Subacute toxicity and endocrine-disrupting effects of Fe2O3, ZnO, and CeO2 nanoparticles on amphibian metamorphosis
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Heidelberg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study evaluated the potential toxic and endocrine-disrupting effects of sublethal concentrations of Fe2O3, CeO2 and ZnO nanoparticles (NPs) on amphibian metamorphosis. Tadpoles were exposed to several NPs concentrations, reaching a maximum of 1000 mu g/L, for up to 21 days according to the amphibian metamorphosis assay (AMA). Some standard morphological parameters, such as developmental stage (DS), hind limb length (HLL), snout-to-vent length (SVL), wet body weight (WBW), and as well as post-exposure lethality were recorded in exposed organisms on days 7 and 21 of the bioassay. Furthermore, triiodothyronine (T3), thyroxine (T4) and malondialdehyde (MDA) levels and the activities of glutathione S-transferases (GST), glutathione reductase (GR), catalase (CAT), carboxylesterase (CaE), and acetylcholinesterase (AChE) were determined in exposed tadpoles as biomarkers. The results indicate that short-term exposure to Fe2O3 NPs leads to toxic effects, both exposure periods cause toxic effects and growth inhibition for ZnO NPs, while short-term exposure to CeO2 NPs results in toxic effects and long-term exposure causes endocrine-disrupting effects. The responses observed after exposure to the tested NPs during amphibian metamorphosis suggest that they may have ecotoxicological effects and their effects should be monitored through field studies.
Açıklama
Anahtar Kelimeler
Xenopus laevis, Nanoparticle, Amphibian metamorphosis assay, Biomarkers
Kaynak
Environmental Science and Pollution Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
31
Sayı
3
