Subacute toxicity and endocrine-disrupting effects of Fe2O3, ZnO, and CeO2 nanoparticles on amphibian metamorphosis

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dc.authoridGungordu, Abbas/0000-0001-7770-0660
dc.authorwosidGungordu, Abbas/A-3009-2015
dc.contributor.authorArslan, Eren
dc.contributor.authorGungordu, Abbas
dc.date.accessioned2024-08-04T20:55:00Z
dc.date.available2024-08-04T20:55:00Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study evaluated the potential toxic and endocrine-disrupting effects of sublethal concentrations of Fe2O3, CeO2 and ZnO nanoparticles (NPs) on amphibian metamorphosis. Tadpoles were exposed to several NPs concentrations, reaching a maximum of 1000 mu g/L, for up to 21 days according to the amphibian metamorphosis assay (AMA). Some standard morphological parameters, such as developmental stage (DS), hind limb length (HLL), snout-to-vent length (SVL), wet body weight (WBW), and as well as post-exposure lethality were recorded in exposed organisms on days 7 and 21 of the bioassay. Furthermore, triiodothyronine (T3), thyroxine (T4) and malondialdehyde (MDA) levels and the activities of glutathione S-transferases (GST), glutathione reductase (GR), catalase (CAT), carboxylesterase (CaE), and acetylcholinesterase (AChE) were determined in exposed tadpoles as biomarkers. The results indicate that short-term exposure to Fe2O3 NPs leads to toxic effects, both exposure periods cause toxic effects and growth inhibition for ZnO NPs, while short-term exposure to CeO2 NPs results in toxic effects and long-term exposure causes endocrine-disrupting effects. The responses observed after exposure to the tested NPs during amphibian metamorphosis suggest that they may have ecotoxicological effects and their effects should be monitored through field studies.en_US
dc.description.sponsorshipInn niversitesi [2019/1830]; Inonu University Research Funden_US
dc.description.sponsorshipThis study was supported by the Inonu University Research Fund (project no.: 2019/1830). The authors wish to thank the supporting institution.en_US
dc.identifier.doi10.1007/s11356-023-31441-4
dc.identifier.endpage4195en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue3en_US
dc.identifier.pmid38097842en_US
dc.identifier.scopus2-s2.0-85182954859en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4174en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-023-31441-4
dc.identifier.urihttps://hdl.handle.net/11616/101774
dc.identifier.volume31en_US
dc.identifier.wosWOS:001125959900010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectXenopus laevisen_US
dc.subjectNanoparticleen_US
dc.subjectAmphibian metamorphosis assayen_US
dc.subjectBiomarkersen_US
dc.titleSubacute toxicity and endocrine-disrupting effects of Fe2O3, ZnO, and CeO2 nanoparticles on amphibian metamorphosisen_US
dc.typeArticleen_US

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