The prevalence of lymphoid follicles and intestinal metaplasia in Helicobacter pylori associated clinically significant gastroduodenal diseases
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Gastroenterology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study was designed to investigate the prevalence of lymphoid follicle formation and intestinal metaplasia in patients with Helicobacter pylori (H.pylori) associated clinically significant diseases. Biopsies from the antrum, corpus and fundus of stomach were obtained from 153 patients (non-ulcer dyspepsia, n:110; duodenal ulcer n:23, duodenal ulcer complicated by obstruction, n:20) with histopathologically proven H. pylori infection. All biopsies were examined for lymphoid follicle with germinal center and intestinal metaplasia. Lymphoid follicles were found in 44.5% of non-ulcer disypeptic patients, 70% of duodenal ulcer complicated by obstruction patients and in 47.8% of uncomplicated duodenal ulcer patients. In contrast, 15.5% of non-ulcer disypeptic patients and 20% of complicated duodenal ulcer patients had associated intestinal metaplasia while no intestinal metaplasia was observed in uncomplicated duodenal ulcer patients. Intestinal metaplasia incidence was not statistically different among the different gastroduodenal pathologies (P>0.05). However the incidence of lymphoid follicles was significantly higher in patients with complicated duodenal ulcer (P<0.05). Our results indicate that H.pylori infection in complicated duodenal ulcers are relatively chronic and aggressive compared to H.pylori infection in other gastroduodenal disorders.
Açıklama
Anahtar Kelimeler
H. pylori, Intestinal metaplasia, Lymphoid follicle
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
10
Sayı
3
